New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.
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Keeping mtDNA in shape between generationsMitochondrial DNA disease and developmental implications for reproductive strategiesFemale and male gamete mitochondria are distinct and complementary in transcription, structure, and genome functionA wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.Transmission of mitochondrial DNA diseases and ways to prevent them.Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans.Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.De novo mtDNA point mutations are common and have a low recurrence risk.The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates.Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognitionMaternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA.Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.The genetics of Leigh syndrome and its implications for clinical practice and risk managementMitochondrial dynamics and inheritance during cell division, development and disease.Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model systemMitochondrial DNA: impacting central and peripheral nervous systems.Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans.Lack of Structural Variation but Extensive Length Polymorphisms and Heteroplasmic Length Variations in the Mitochondrial DNA Control Region of Highly Inbred Crested Ibis, Nipponia nippon.Mitochondrial DNA mutations in disease and agingMitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCsMitochondrial disease in childhood: mtDNA encoded.The impact of darwinian evolution on medicine: the maternal side of the story.Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.Dynamic regulation of mitochondrial genome maintenance in germ cells.Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) genemtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Mitochondrial matters: Mitochondrial bottlenecks, self-assembling structures, and entrapment in the female germline.Genetic Counselling for Maternally Inherited Mitochondrial Disorders.The molecular characterization of porcine egg precursor cells.Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS.Experience from the First Live-Birth Derived From Oocyte Nuclear Transfer as a Treatment Strategy for Mitochondrial Diseases.Establishment of a heteroplasmic mouse strain with interspecific mitochondrial DNA haplotypes and improvement of a PCR-RFLP-based measurement system for estimation of mitochondrial DNA heteroplasmy.Assisted reproductive technologies to prevent human mitochondrial disease transmission.Multiple ways to prevent transmission of paternal mitochondrial DNA for maternal inheritance in animals.Mitigating Mitochondrial Genome Erosion Without Recombination.The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.A history of mitochondrial diseases.Mitochondrial DNA transmission and confounding mitochondrial influences in cloned cattle and pigs.
P2860
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P2860
New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
New evidence confirms that the ...... primordial germ cells of mice.
@ast
New evidence confirms that the ...... primordial germ cells of mice.
@en
New evidence confirms that the ...... primordial germ cells of mice.
@nl
type
label
New evidence confirms that the ...... primordial germ cells of mice.
@ast
New evidence confirms that the ...... primordial germ cells of mice.
@en
New evidence confirms that the ...... primordial germ cells of mice.
@nl
prefLabel
New evidence confirms that the ...... primordial germ cells of mice.
@ast
New evidence confirms that the ...... primordial germ cells of mice.
@en
New evidence confirms that the ...... primordial germ cells of mice.
@nl
P2093
P2860
P1433
P1476
New evidence confirms that the ...... primordial germ cells of mice.
@en
P2093
Hiromichi Yonekawa
Hiroshi Shitara
Jun-Ichi Hayashi
Kuniya Abe
Michihiko Sugimoto
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000756
P577
2009-12-04T00:00:00Z