Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. - Wikidata - wikimedia - TriplyDB

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

http://www.wikidata.org/entity/Q33530396

about

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing A computational model predicting disruption of blood vessel development Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate Addressing human variability in next-generation human health risk assessments of environmental chemicals Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data CERAPP: Collaborative Estrogen Receptor Activity Prediction Project Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.Development and Validation of a Computational Model for Androgen Receptor Activity Endocrine profiling and prioritization of environmental chemicals using ToxCast data Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st century.Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective Genetic toxicology in the 21st century: reflections and future directions.Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model In Silico Study of In Vitro GPCR Assays by QSAR Modeling.Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.In vitro bioassays to evaluate complex chemical mixtures in recycled water.Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis.Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays Improving the human hazard characterization of chemicals: a Tox21 update On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens.Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme.SEURAT-1 liver gold reference compounds: a mechanism-based review.Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.Endocrine Disruption and In Vitro Ecotoxicology: Recent Advances and Approaches.In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning.Understanding bioavailability and toxicity of sediment-associated contaminants by combining passive sampling with in vitro bioassays in an urban river catchment.Pathway Based Toxicology and Fit-for-Purpose Assays.Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

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P2860

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

http://www.wikidata.org/entity/Q33530396

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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