Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential
about
A structural role for the PHP domain in E. coli DNA polymerase IIIA bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.A small molecule inhibitor of Pot1 binding to telomeric DNA.Breaking the rules: bacteria that use several DNA polymerase IIIs.Bacterial replicases and related polymerasesArchitecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.The β2 clamp in the Mycobacterium tuberculosis DNA polymerase III αβ2ε replicase promotes polymerization and reduces exonuclease activity.The PriA replication restart protein blocks replicase access prior to helicase assembly and directs template specificity through its ATPase activity.Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design.The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.
P2860
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P2860
Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Parallel multiplicative target ...... with broad spectrum potential
@ast
Parallel multiplicative target ...... with broad spectrum potential
@en
Parallel multiplicative target ...... with broad spectrum potential.
@nl
type
label
Parallel multiplicative target ...... with broad spectrum potential
@ast
Parallel multiplicative target ...... with broad spectrum potential
@en
Parallel multiplicative target ...... with broad spectrum potential.
@nl
prefLabel
Parallel multiplicative target ...... with broad spectrum potential
@ast
Parallel multiplicative target ...... with broad spectrum potential
@en
Parallel multiplicative target ...... with broad spectrum potential.
@nl
P2093
P2860
P356
P1433
P1476
Parallel multiplicative target ...... with broad spectrum potential
@en
P2093
Anna Wiktor-Becker
Casey Pope
Charles S McHenry
H Garry Dallmann
Laurie S Kaguni
Oliver J Fackelmayer
Peter M J Burgers
Tracey Ferrara
P2860
P304
P356
10.1021/BI9020764
P407
P577
2010-03-01T00:00:00Z