Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.
about
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexesThe E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsJanus kinases in immune cell signalingAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationAn intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor IIPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationA direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinaseNegative regulation of cytokine signaling and immune responses by SOCS proteinsUbiquitin-mediated NFκB degradation pathwayThe role of suppressors of cytokine signalling in human neoplasmsStructural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin LigaseThe SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoTyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancerATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells.ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation.Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.Regulation of cytokine receptor signaling by SOCS1.Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5α-induced inhibition of human immunodeficiency virus type-1 production.Are SOCS suppressors, regulators, and degraders?Regulation of TLR signaling and inflammation by SOCS family proteins.The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.Negative regulation of FAK signaling by SOCS proteins.Regulation of inflammation by interleukin-4: a review of "alternatives"Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemiaSLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.JAK Kinases in Health and Disease: An UpdateSOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells.Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy.Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell lineUbiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells.Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafishSOCS regulation of the JAK/STAT signalling pathway.
P2860
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P2860
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@ast
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@en
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@nl
type
label
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@ast
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@en
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@nl
prefLabel
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@ast
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@en
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@nl
P2093
P2860
P1476
Socs-1 inhibits TEL-JAK2-media ...... oteasome-mediated degradation.
@en
P2093
D G Gilliland
D W Sternberg
J Frantsve
J Schwaller
P2860
P304
P356
10.1128/MCB.21.10.3547-3557.2001
P407
P577
2001-05-01T00:00:00Z