Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.
about
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignanciesPKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemiaDeciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compoundsBroad targeting of resistance to apoptosis in cancer.Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition?A clinician's guide to double hit lymphomas.Chronic lymphocytic leukemia (CLL)-Then and now.Chronic lymphocytic leukemia: Time to go past genomics?Breakthrough therapies in B-cell non-Hodgkin lymphoma.Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.Selective Inhibitors of Nuclear Export (SINE) compounds block proliferation and migration of triple negative breast cancer cells by restoring expression of ARRDC3.Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration.Identification of key miRNA-gene pairs in chronic lymphocytic leukemia through integrated analysis of mRNA and miRNA microarray.BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor.Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1.Nuclear Export Inhibition for Pancreatic Cancer Therapy.
P2860
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P2860
Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@ast
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@en
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@nl
type
label
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@ast
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@en
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@nl
prefLabel
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@ast
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@en
Selinexor suppresses downstrea ...... ic lymphocytic leukemia cells.
@nl
P2093
P2860
P356
P1433
P1476
Selinexor suppresses downstrea ...... nic lymphocytic leukemia cells
@en
P2093
D El-Gamal
D McCauley
J A Dubovsky
K A Beckwith
K E Williams
K J Maddocks
L A Andritsos
P2860
P2888
P304
P356
10.1038/LEU.2014.9
P577
2014-01-13T00:00:00Z
P6179
1022425376