Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
about
Developmental disease and cancer: biological and clinical overlapsMourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complexHaploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation.BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development.Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.A continuum model for tumour suppression.Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells.Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes.Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.APC +/- alters colonic fibroblast proteome in FAP.Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell deathStress and breast cancer: from epidemiology to molecular biology.Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.A novel role for the condensin II complex in cellular senescence.Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers.Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivoAccelerated geroncogenesis in hereditary breast-ovarian cancer syndromeEZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells.Heritable one-hit events defining cancer prevention?Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer.Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers.DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers.Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers.SYK expression level distinguishes control from BRCA1-mutated lymphocytes.
P2860
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P2860
Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@ast
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@en
Altered gene expression in mor ...... s of BRCA1 or BRCA2 mutations.
@nl
type
label
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@ast
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@en
Altered gene expression in mor ...... s of BRCA1 or BRCA2 mutations.
@nl
prefLabel
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@ast
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@en
Altered gene expression in mor ...... s of BRCA1 or BRCA2 mutations.
@nl
P2093
P2860
P1476
Altered gene expression in mor ...... rs of BRCA1 or BRCA2 mutations
@en
P2093
Alfonso Bellacosa
Alfred G Knudson
Andrew K Godwin
Anthony T Yeung
Betsy Bove
Carolyn Slater
Elena Caretti
Emmanuelle Nicolas
Henry T Lynch
P2860
P356
10.1158/1940-6207.CAPR-09-0078
P577
2010-01-01T00:00:00Z