Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. - Wikidata - wikimedia - TriplyDB

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

http://www.wikidata.org/entity/Q33591955

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MIF: Implications in the Pathoetiology of Systemic Lupus Erythematosus Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)Structural Interactions Dictate the Kinetics of Macrophage Migration Inhibitory Factor Inhibition by Different Cancer-Preventive Isothiocyanates Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the β-sheet structure of MIF.MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development.Benzisothiazolones as modulators of macrophage migration inhibitory factor.Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection.Arrest Functions of the MIF Ligand/Receptor Axes in Atherogenesis.Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF)Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life.CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease.Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities.MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics.Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action.Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.MIF inhibition interferes with the inflammatory and T cell-stimulatory capacity of NOD macrophages and delays autoimmune diabetes onset.Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning.MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor.Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach.Discovery of Novel Inhibitors of the Tautomerase Activity of Macrophage Migration Inhibitory Factor (MIF).Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity.Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation.

P2860

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P2860

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

http://www.wikidata.org/entity/Q33591955

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Identification and characteriz ...... distinct mechanisms of action.

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Identification and characteriz ...... distinct mechanisms of action.

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Identification and characteriz ...... distinct mechanisms of action.

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Identification and characteriz ...... distinct mechanisms of action.

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Identification and characteriz ...... distinct mechanisms of action.

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Identification and characteriz ...... distinct mechanisms of action.

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JBC.M110.113951

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Journal of Biological Chemistry

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Identification and characteriz ...... distinct mechanisms of action.

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Damla Pinar Karpinar

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Farah El-Turk

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Hajer Ouertatani-Sakouhi

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Jürgen Bernhagen

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Manfred Dewor

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P2860

Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation

Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor

Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor

The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction

Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography

The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor Active Site Interactions † ‡

The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction

Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases

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