Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis
about
The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymeraseAn Alternative σ Factor, σ8, Controls Avermectin Production and Multiple Stress Responses in Streptomyces avermitilis.Systematics-guided bioprospecting for bioactive microbial natural products.A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity.Genome plasticity and systems evolution in Streptomyces.Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.Verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, Penicillium aurantiogriseumEndophytic Streptomyces sp. Y3111 from traditional Chinese medicine produced antitubercular pluramycins.FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensisSystems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis.Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces.Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites.Tentative biosynthetic pathways of some microbial diketopiperazines.Synthetic biology of avermectin for production improvement and structure diversification.Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Engineering microbial hosts for production of bacterial natural productsLincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis.Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10.Rational selection and engineering of exogenous principal sigma factor (σ(HrdB)) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus.An insight into the "-omics" based engineering of streptomycetes for secondary metabolite overproduction.Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers.Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains.Interrogation of Streptomyces avermitilis for efficient production of avermectins.AvaR1, a Butenolide-Type Autoregulator Receptor in Streptomyces avermitilis, Directly Represses Avenolide and Avermectin Biosynthesis and Multiple Physiological Responses.AvaR2, a pseudo γ-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth.Connecting Metabolic Pathways: Sigma Factors in Streptomyces spp.Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale.Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis.An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis.The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis.Different fates of avermectin and artemisinin in China.6S RNA modulates growth and antibiotic production in Streptomyces coelicolor.Organic Peroxide-Sensing Repressor OhrR Regulates Organic Hydroperoxide Stress Resistance and Avermectin Production in Streptomyces avermitilis.Activation of microbial secondary metabolic pathways: Avenues and challenges
P2860
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P2860
Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Reverse biological engineering ...... in of Streptomyces avermitilis
@ast
Reverse biological engineering ...... in of Streptomyces avermitilis
@en
type
label
Reverse biological engineering ...... in of Streptomyces avermitilis
@ast
Reverse biological engineering ...... in of Streptomyces avermitilis
@en
prefLabel
Reverse biological engineering ...... in of Streptomyces avermitilis
@ast
Reverse biological engineering ...... in of Streptomyces avermitilis
@en
P2093
P2860
P356
P1476
Reverse biological engineering ...... in of Streptomyces avermitilis
@en
P2093
Bang-Ce Ye
Difei Chen
Li-Xin Zhang
Qing Zhang
Siliang Zhang
Wenquan Zhang
Xianlong Zhou
Zhongxuan Gou
P2860
P304
11250-11254
P356
10.1073/PNAS.1006085107
P407
P577
2010-06-07T00:00:00Z