Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development.
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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexNailing down a link between tuberin and renal cystsHamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and BTuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosisEpilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in ratsA germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in miceTuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patientsRheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.mTOR regulates brain morphogenesis by mediating GSK3 signaling.Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens.Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathwayLong-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis.Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis.mTOR couples cellular nutrient sensing to organismal metabolic homeostasisGenetics and molecular biology of tuberous sclerosis complex.Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.CHO cells knocked out for TSC2 display an improved productivity of antibodies under fed batch conditions.Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex.Importance of tuberin in carcinogenesis.Irradiation exacerbates cortical cytopathology in the Eker rat model of tuberous sclerosis complex, but does not induce hyperexcitability.Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus.mTOR signaling in stem and progenitor cells.[Curing mental retardation: searching for balance].
P2860
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P2860
Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Loss of function of the tubero ...... helial growth and development.
@ast
Loss of function of the tubero ...... helial growth and development.
@en
type
label
Loss of function of the tubero ...... helial growth and development.
@ast
Loss of function of the tubero ...... helial growth and development.
@en
prefLabel
Loss of function of the tubero ...... helial growth and development.
@ast
Loss of function of the tubero ...... helial growth and development.
@en
P2093
P2860
P356
P1476
Loss of function of the tubero ...... helial growth and development.
@en
P2093
C L Walker
E V Kleymenova
G Rennebeck
R Anderson
P2860
P304
15629-15634
P356
10.1073/PNAS.95.26.15629
P407
P577
1998-12-01T00:00:00Z