Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus
about
Recombinant mouse hepatitis virus strain A59 from cloned, full-length cDNA replicates to high titers in vitro and is fully pathogenic in vivoMurine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein.Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis.Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion.A mechanism of virus-induced demyelination.Coronaviruses induce entry-independent, continuous macropinocytosisPathogenesis of murine coronavirus in the central nervous system.Identification of novel functional regions within the spike glycoprotein of MHV-A59 based on a bioinformatics approachGenetic determinants of mouse hepatitis virus strain 1 pneumovirulence.Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis.Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis.Mouse hepatitis virus infection upregulates genes involved in innate immune responses.Deficient incorporation of spike protein into virions contributes to the lack of infectivity following establishment of a persistent, non-productive infection in oligodendroglial cell culture by murine coronavirus.Both spike and background genes contribute to murine coronavirus neurovirulenceMurine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropismAnalysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virusInduction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection.Differential induction of proinflammatory cytokines in primary mouse astrocytes and microglia by coronavirus infectionGliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis VirusDemyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropismInduction of caspase-dependent apoptosis in cultured rat oligodendrocytes by murine coronavirus is mediated during cell entry and does not require virus replication.Microglia play a major role in direct viral-induced demyelinationCoronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine signals from astrocytes and microglia.Mechanisms of primary axonal damage in a viral model of multiple sclerosis.The spike protein of murine coronavirus regulates viral genome transport from the cell surface to the endoplasmic reticulum during infection.Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infectionEffect of microtubule disruption on neuronal spread and replication of demyelinating and nondemyelinating strains of mouse hepatitis virus in vitro.Expression of cellular oncogene Bcl-xL prevents coronavirus-induced cell death and converts acute infection to persistent infection in progenitor rat oligodendrocytesMicroglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology.The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain.Mouse Hepatitis Virus Infection Remodels Connexin43-Mediated Gap Junction Intercellular Communication In Vitro and In Vivo.Recombinant avian infectious bronchitis virus expressing a heterologous spike gene demonstrates that the spike protein is a determinant of cell tropismEndosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry.Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.Recombinant infectious bronchitis coronavirus Beaudette with the spike protein gene of the pathogenic M41 strain remains attenuated but induces protective immunity.Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice.Rapid selection in chickens of subpopulations within ArkDPI-derived infectious bronchitis virus vaccines.
P2860
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P2860
Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
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@wuu
name
Demyelination determinants map ...... onavirus mouse hepatitis virus
@ast
Demyelination determinants map ...... onavirus mouse hepatitis virus
@en
type
label
Demyelination determinants map ...... onavirus mouse hepatitis virus
@ast
Demyelination determinants map ...... onavirus mouse hepatitis virus
@en
prefLabel
Demyelination determinants map ...... onavirus mouse hepatitis virus
@ast
Demyelination determinants map ...... onavirus mouse hepatitis virus
@en
P2093
P2860
P1433
P1476
Demyelination determinants map ...... onavirus mouse hepatitis virus
@en
P2093
P2860
P304
P356
10.1128/JVI.74.19.9206-9213.2000
P577
2000-10-01T00:00:00Z