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Neurovirulence determinants of genetically engineered Theiler viruses

Neurovirulence determinants of genetically engineered Theiler viruses

http://www.wikidata.org/entity/Q33605933

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Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway Theiler's virus infection: a model for multiple sclerosis A coding RNA sequence acts as a replication signal in cardioviruses Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5'-noncoding region and the E2 envelope glycoprotein Three-dimensional structure of Theiler virus.The neurovirulence of the DA and GDVII strains of Theiler's virus correlates with their ability To infect cultured neurons L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line.A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.L* protein of Theiler's murine encephalomyelitis virus is required for virus growth in a murine macrophage-like cell line.Alternative translation initiation of Theiler's murine encephalomyelitis virus.The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon production.A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence Mutations that affect the tropism of DA and GDVII strains of Theiler's virus in vitro influence sialic acid binding and pathogenicity.Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus.Apoptotic and antiapoptotic activity of L protein of Theiler's murine encephalomyelitis virus.The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells.The neurovirulent GDVII strain of Theiler's virus can replicate in glial cells.Role of VP2 amino acid 141 in tropism of Theiler's virus within the central nervous system.RNA polymerase I-driven reverse genetics system for enterovirus 71 and its implications for vaccine production Assembly of Theiler's virus recombinants used in mapping determinants of neurovirulence.Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses Enhancing the Tumor Selectivity of a Picornavirus Virotherapy Promotes Tumor Regression and the Accumulation of Infiltrating CD8+ T Cells.Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection.cDNA clone of hepatitis A virus encoding a virulent virus: induction of viral hepatitis by direct nucleic acid transfection of marmosets.Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence Strains from both Theiler's virus subgroups encode a determinant for demyelination The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.Infection of macrophage primary cultures by persistent and nonpersistent strains of Theiler's virus: role of capsid and noncapsid viral determinants.Saffold virus, a novel human Cardiovirus with unknown pathogenicity.Role of sialyloligosaccharide binding in Theiler's virus persistence.Analysis of cellular mutants resistant to Theiler's virus infection: differential infection of L929 cells by persistent and neurovirulent strains.Predominant binding of Theiler's viruses to a 34-kilodalton receptor protein on susceptible cell lines.Theiler's murine encephalomyelitis virus leader protein amino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells.Analysis of the molecular basis of neuropathogenesis of RNA viruses in experimental animals: relevance for human disease?

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P2860

Neurovirulence determinants of genetically engineered Theiler viruses

http://www.wikidata.org/entity/Q33605933

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1990 nî lūn-bûn

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1990 թուականի Յունիսին հրատարակուած գիտական յօդուած

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1990 թվականի հունիսին հրատարակված գիտական հոդված

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1990年の論文

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1990年論文

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1990年論文

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1990年論文

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1990年論文

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1990年論文

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1990年论文

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Neurovirulence determinants of genetically engineered Theiler viruses

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Neurovirulence determinants of genetically engineered Theiler viruses

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Neurovirulence determinants of genetically engineered Theiler viruses

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Neurovirulence determinants of genetically engineered Theiler viruses

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Neurovirulence determinants of genetically engineered Theiler viruses

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Neurovirulence determinants of genetically engineered Theiler viruses

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PNAS.87.11.4125

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Proceedings of the National Academy of Sciences of the United States of America

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Neurovirulence determinants of genetically engineered Theiler viruses

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P2093

B L Semler

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J L Fu

http://www.w3.org/2001/XMLSchema#string

L Rosenstein

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M Routbort

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R P Roos

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S Stein

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T Bodwell

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P2860

Retrovirus-induced murine motor neuron disease: mapping the determinant of spongiform degeneration within the envelope gene.

Molecular basis of reovirus virulence: role of the S1 gene.

Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype.

Polyprotein processing of Theiler's murine encephalomyelitis virus.

Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus

Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).

Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence.

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4125-4129

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10.1073/PNAS.87.11.4125

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11

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87

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1990-06-01T00:00:00Z

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20993588

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2161533

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54060

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