Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. - Wikidata - wikimedia - TriplyDB

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.

http://www.wikidata.org/entity/Q33618895

about

Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Centriole assembly and the role of Mps1: defensible or dispensable?Polo-like kinase 4: the odd one out of the family Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication Maintaining Genome Stability in Defiance of Mitotic DNA Damage Centrosomes, chromosome instability (CIN) and aneuploidy p53 protects against genome instability following centriole duplication failure The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication The PLK4-STIL-SAS-6 module at the core of centriole duplication MDM1 is a microtubule-binding protein that negatively regulates centriole duplication Direct kinetochore-spindle pole connections are not required for chromosome segregation.Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes.E2F activators signal and maintain centrosome amplification in breast cancer cells.The centriole duplication cycle.Causes and consequences of centrosome abnormalities in cancer.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.Polo-like kinase 4 inhibition: a strategy for cancer therapy?The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries.Cep152 interacts with Plk4 and is required for centriole duplication.SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis Plk4/SAK/ZYG-1 in the regulation of centriole duplication.Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.Centriole duplication: A lesson in self-control.SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors The centrosome and its duplication cycle Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.Autoinhibition and relief mechanism for Polo-like kinase 4.Centrosome amplification in CHO and DT40 cells by inactivation of cyclin-dependent kinases.The conversion of centrioles to centrosomes: essential coupling of duplication with segregation The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification.

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P2860

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.

http://www.wikidata.org/entity/Q33618895

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@ast

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@en

type

label

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@ast

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@en

prefLabel

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@ast

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@en

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P1433

Journal of Cell Biology

P1476

Polo-like kinase 4 kinase acti ...... oregulating its own stability.

@en

P2093

Andrew J Holland

http://www.w3.org/2001/XMLSchema#string

Heather Hoover

http://www.w3.org/2001/XMLSchema#string

Sherry Niessen

http://www.w3.org/2001/XMLSchema#string

Weijie Lan

http://www.w3.org/2001/XMLSchema#string

P2860

The Polo kinase Plk4 functions in centriole duplication

RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

Global mapping of the topography and magnitude of proteolytic events in apoptosis

Ab ovo or de novo? Mechanisms of centriole duplication

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

A chemical switch for inhibitor-sensitive alleles of any protein kinase

A mechanism linking extra centrosomes to chromosomal instability

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191-198

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scholarly article

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10.1083/JCB.200911102

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P433

2

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188

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Don W Cleveland

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2010-01-01T00:00:00Z

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41139223

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20100909

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2813471

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