Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization. - Wikidata - wikimedia - TriplyDB

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

http://www.wikidata.org/entity/Q33620516

about

Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI Metabolic engineering for the production of natural products.High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.Recombinant E. coli prototype strains for in vivo glycorandomization.Probing the aglycon promiscuity of an engineered glycosyltransferase Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning.The impact of enzyme engineering upon natural product glycodiversification Recent progress in chemical and chemoenzymatic synthesis of carbohydrates Asymmetric enzymatic glycosylation of mitoxantrone Engineering a Carbohydrate-processing Transglycosidase into Glycosyltransferase for Natural Product Glycodiversification.Microbial production of next-generation stevia sweeteners Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.Assessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors.Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis Realizing the Promise of Chemical Glycobiology.Opportunities for enzyme engineering in natural product biosynthesis.Directed evolution: new parts and optimized function Introducing N-glycans into natural products through a chemoenzymatic approach.Protein engineering towards natural product synthesis and diversification.Bacterial Glycosyltransferases: Challenges and Opportunities of a Highly Diverse Enzyme Class Toward Tailoring Natural Products.Glycosyltransferases: mechanisms and applications in natural product development.Glycosyltransferase engineering for carbohydrate synthesis.Fitness loss and library size determination in saturation mutagenesis Development of a universal glycosyltransferase assay amenable to high-throughput formats.Diversifying Natural Products with Promiscuous Glycosyltransferase Enzymes via a Sustainable Microbial Fermentation Approach.3-β-Glucosyl-3'-β-quinovosyl zeaxanthin, a novel carotenoid glycoside synthesized by Escherichia coli cells expressing the Pantoea ananatis carotenoid biosynthesis gene cluster.Biosynthetic 4,6-dehydratase gene deletion: isolation of a glucosylated jadomycin natural product provides insight into the substrate specificity of glycosyltransferase JadS.

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P2860

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

http://www.wikidata.org/entity/Q33620516

description

2008 nî lūn-bûn

@nan

2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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J.CHEMBIOL.2008.02.017

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Chemistry and Biology

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Optimizing glycosyltransferase ...... novobiocin glycorandomization.

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P2093

Changsheng Zhang

http://www.w3.org/2001/XMLSchema#string

Gavin J Williams

http://www.w3.org/2001/XMLSchema#string

Jon S Thorson

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Randal D Goff

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P2860

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

The ATP-binding site of type II topoisomerases as a target for antibacterial drugs

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

Natural product glycosyltransferases: properties and applications

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10.1016/J.CHEMBIOL.2008.02.017

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4

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