Polycomb target genes are silenced in multiple myeloma. - Wikidata - wikimedia - TriplyDB

Polycomb target genes are silenced in multiple myeloma.

Polycomb target genes are silenced in multiple myeloma.

http://www.wikidata.org/entity/Q33633898

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Evolving paradigms in the treatment of relapsed/refractory multiple myeloma: increased options and increased complexity EZH2 in normal hematopoiesis and hematological malignancies The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective Novel therapeutic strategies for multiple myeloma Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells Deacetylase inhibitors: an advance in myeloma therapy?Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications.Regulation and Role of EZH2 in Cancer BMI-1 autoantibody as a new potential biomarker for cervical carcinoma.Proteomic analysis of endothelial cold-adaptation Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma.(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas.Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression Clonogenic multiple myeloma cells have shared stemness signature associated with patient survival Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability.A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma.EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality.Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma Epigenetic modulating agents as a new therapeutic approach in multiple myeloma.Current and potential epigenetic targets in multiple myeloma.The role of polycomb repressive complexes in biliary tract cancer.Targeting of cancer stem cells by inhibitors of DNA and histone methylation.Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma.Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes.Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2--implications for a combinatorial treatment.The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).Role of epigenetics-microRNA axis in drug resistance of multiple myeloma.Regulation of cancer epigenomes with a histone-binding synthetic transcription factor.Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition.Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model.

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P2860

Polycomb target genes are silenced in multiple myeloma.

http://www.wikidata.org/entity/Q33633898

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Polycomb target genes are silenced in multiple myeloma.

@ast

Polycomb target genes are silenced in multiple myeloma.

@en

type

label

Polycomb target genes are silenced in multiple myeloma.

@ast

Polycomb target genes are silenced in multiple myeloma.

@en

prefLabel

Polycomb target genes are silenced in multiple myeloma.

@ast

Polycomb target genes are silenced in multiple myeloma.

@en

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JOURNAL.PONE.0011483

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Polycomb target genes are silenced in multiple myeloma.

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Anders Osterborg

http://www.w3.org/2001/XMLSchema#string

Charlotte Fristedt

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Fredrik Oberg

http://www.w3.org/2001/XMLSchema#string

Helena Jernberg-Wiklund

http://www.w3.org/2001/XMLSchema#string

Karin Vanderkerken

http://www.w3.org/2001/XMLSchema#string

Kenneth Nilsson

http://www.w3.org/2001/XMLSchema#string

Maria Eriksson

http://www.w3.org/2001/XMLSchema#string

Miguel Lemaire

http://www.w3.org/2001/XMLSchema#string

Mårten Fryknäs

http://www.w3.org/2001/XMLSchema#string

Peter Atadja

http://www.w3.org/2001/XMLSchema#string

P2860

The Polycomb group protein EZH2 directly controls DNA methylation

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Characterization of clonogenic multiple myeloma cells

Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

ONCOMINE: a cancer microarray database and integrated data-mining platform

Polycomb silencing mechanisms and the management of genomic programmes

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Mechanisms of polycomb gene silencing: knowns and unknowns

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Antonia Kalushkova

Prasoon Agarwal

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2010-07-09T00:00:00Z

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45200457

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