Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity
about
Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathwayA pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activityA cross-metathesis approach to novel pantothenamide derivatives.Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activityChemical biology tools to study pantetheinases of the vanin family.Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Novel pantothenate derivatives for anti-malarial chemotherapy.Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.
P2860
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P2860
Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural modification of pan ...... proves antiplasmodial activity
@ast
Structural modification of pan ...... proves antiplasmodial activity
@en
type
label
Structural modification of pan ...... proves antiplasmodial activity
@ast
Structural modification of pan ...... proves antiplasmodial activity
@en
prefLabel
Structural modification of pan ...... proves antiplasmodial activity
@ast
Structural modification of pan ...... proves antiplasmodial activity
@en
P2860
P50
P356
P1476
Structural modification of pan ...... proves antiplasmodial activity
@en
P2093
Cristiano Macuamule
Yoo-Min Hyun
P2860
P304
P356
10.1021/ML400180D
P577
2013-06-17T00:00:00Z