Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.
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Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activityGlycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.Obesity and cancer progression: is there a role of fatty acid metabolism?Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genesMice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid compositionCharacterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testisArylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cellsMolecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutumInhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.Macrobrachium borellii hepatopancreas contains a mitochondrial glycerol-3-phosphate acyltransferase which initiates triacylglycerol biosynthesis.Genetic control of de novo lipogenesis: role in diet-induced obesityAdipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisGlycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerolsStudies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.Ncb5or deficiency increases fatty acid catabolism and oxidative stress.Glycerophosphate/Acylglycerophosphate acyltransferases.Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingDesign and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors.Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown AdipocytesRole of Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase in Oleaginous Streptomyces sp. Strain G25.Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid HomeostasisMice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancerMitochondria-type GPAT is required for mitochondrial fusionEicosanoids in metabolic syndrome.Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidationBiochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.Lipodystrophies: disorders of adipose tissue biology.Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression.Milk lipid secretion: recent biomolecular aspects.Chemical modulation of glycerolipid signaling and metabolic pathways.Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors.Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β.
P2860
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P2860
Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@ast
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@en
type
label
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@ast
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@en
prefLabel
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@ast
Identification of a novel sn-g ...... e deficient in Agpat6-/- mice.
@en
P2093
P2860
P1476
Identification of a novel sn-g ...... me deficient in Agpat6-/- mice
@en
P2093
Cynthia A Nagle
Hendrik Dejong
Rosalind A Coleman
Shuli Wang
Tal M Lewin
P2860
P304
P356
10.1194/JLR.M700592-JLR200
P577
2008-01-11T00:00:00Z