A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
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Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entryVirion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick GetawayHerpesvirus gB: A Finely Tuned Fusion MachineStuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entryMechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109Importance of Highly Conserved Peptide Sites of Human Cytomegalovirus gO for Formation of the gH/gL/gO Complex.A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cellsHuman cytomegalovirus TR strain glycoprotein O acts as a chaperone promoting gH/gL incorporation into virions but is not present in virionsHCMV spread and cell tropism are determined by distinct virus populations.Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner.Herpes virus fusion and entry: a story with many characters.PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway.Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infectionRhesus and human cytomegalovirus glycoprotein L are required for infection and cell-to-cell spread of virus but cannot complement each other.Vaccine-induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques.Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodiesThe HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell typesComplete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gOA viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism.Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells.Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for CytomegalovirusPhase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults.Scanning Mutagenesis of Human Cytomegalovirus Glycoprotein gH/gL.Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism.Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions.A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig CytomegalovirusThe US16 gene of human cytomegalovirus is required for efficient viral infection of endothelial and epithelial cells.Antibodies against the gH/gL/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin.Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection.Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.HCMV gB shares structural and functional properties with gB proteins from other herpesviruses.Cytomegalovirus vaccines and methods of production (WO20009049138): the emerging recognition of the importance of virus neutralization at the epithelial/endothelial interfaceA vaccine based on the rhesus cytomegalovirus UL128 complex induces broadly neutralizing antibodies in rhesus macaques.The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gLHuman cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein.Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation.Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope.
P2860
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P2860
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
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name
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@ast
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@en
type
label
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@ast
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@en
prefLabel
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@ast
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@en
P2093
P2860
P356
P1433
P1476
A human cytomegalovirus gO-nul ...... ithelial and endothelial cells
@en
P2093
Amber J Knoche
David C Johnson
Jay A Nelson
Paul T Wille
P2860
P304
P356
10.1128/JVI.02249-09
P577
2009-12-23T00:00:00Z