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Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles

http://www.wikidata.org/entity/Q33658642

about

HIV reservoirs and immune surveillance evasion cause the failure of structured treatment interruptions: a computational study Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors Ex vivo gene therapy for HIV-1 treatment.A quantitative comparison of anti-HIV gene therapy delivered to hematopoietic stem cells versus CD4+ T cells.HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites.Antiviral RNAi: translating science towards therapeutic success.Creating genetic resistance to HIV.Potential mechanisms for cell-based gene therapy to treat HIV/AIDS.Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor.

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P2860

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles

http://www.wikidata.org/entity/Q33658642

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Computational models of HIV-1 ...... date therapy design principles

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Computational models of HIV-1 ...... date therapy design principles

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JOURNAL.PCBI.1000883

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PLOS Computational Biology

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Computational models of HIV-1 ...... date therapy design principles

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P2093

David V Schaffer

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Priya S Shah

http://www.w3.org/2001/XMLSchema#string

Sharon Aviran

http://www.w3.org/2001/XMLSchema#string

P2860

Evolution of mutational robustness in an RNA virus

Evidence for Positive Epistasis in HIV-1

Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance

Gene transfer in humans using a conditionally replicating lentiviral vector

CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection

MicroRNAs modulate hematopoietic lineage differentiation

Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir

Optimal timing and duration of induction therapy for HIV-1 infection

Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy

Timing the emergence of resistance to anti-HIV drugs with large genetic barriers

P31

scholarly article

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10.1371/JOURNAL.PCBI.1000883

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8

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20711350

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2920833

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