Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. - Wikidata - wikimedia - TriplyDB

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

http://www.wikidata.org/entity/Q33668232

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The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.The serotonin system in autism spectrum disorder: From biomarker to animal models Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance An integrative view of microbiome-host interactions in inflammatory bowel diseases Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive?Serotonin and colonic motility.RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats.Dual Role of Endogenous Serotonin in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis.The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice.Role of transient receptor potential channels in intestinal inflammation and visceral pain: novel targets in inflammatory bowel diseases.Intestinal barrier homeostasis in inflammatory bowel disease.5-HT7 receptor signaling: improved therapeutic strategy in gut disorders Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome Enteric Serotonin and Oxytocin: Endogenous Regulation of Severity in a Murine Model of Necrotizing Enterocolitis.Novel investigational drugs for constipation-predominant irritable bowel syndrome: a review.Listeria monocytogenes Inhibits Serotonin Transporter in Human Intestinal Caco-2 Cells.Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors.Enteric Neuronal Regulation of Intestinal Inflammation.The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice.Telotristat ethyl: a new option for the management of carcinoid syndrome.Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure.Non-conventional features of peripheral serotonin signalling - the gut and beyond.Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease.Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.Anticolitis activity of Chinese herbal formula yupingfeng powder via regulating colonic enterochromaffin cells and serotonin.Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release.Analysis of enteroendocrine cell populations in the human colon.Selective inhibition of mucosal serotonin as treatment for IBD?Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism.A sexually dimorphic effect of cholera toxin: rapid changes in colonic motility mediated via a 5-HT3 receptor-dependent pathway in female C57Bl/6 mice.Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.Developments in the treatment of carcinoid syndrome - impact of telotristat.Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites.Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks.

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P2860

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

http://www.wikidata.org/entity/Q33668232

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2013年の論文

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Pharmacological reduction of m ...... flammation in mouse intestine.

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Brian Zambrowicz

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Kanchan G Jhaver

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Kara Gross Margolis

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Korey Stevanovic

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Qi Melissa Yang

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P2860

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome

Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

Synthesis of serotonin by a second tryptophan hydroxylase isoform

Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice.

Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract.

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