New roles for the major human 3'-5' exonuclease TREX1 in human disease. - Wikidata - wikimedia - TriplyDB

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

http://www.wikidata.org/entity/Q33671295

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Intracellular nucleic acid sensors and autoimmunity Structural basis for RNA trimming by RNase T in stable RNA 3'-end maturation How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes Aberrant Type I Interferon Regulation in Autoimmunity: Opposite Directions in MS and SLE, Shaped by Evolution and Body Ecology RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases Migraine aura pathophysiology: the role of blood vessels and microembolisation Genetic associations in type I interferon related pathways with autoimmunity Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression Aicardi-Goutieres syndrome.Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.Hereditary endotheliopathy with retinopathy and encephalopathy: pathological and genetic studies of a family Inflammation-driven carcinogenesis is mediated through STING The TREX1 C-terminal region controls cellular localization through ubiquitination.MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment cAMP responsive element modulator: a critical regulator of cytokine production Review: molecular genetics and pathology of hereditary small vessel diseases of the brain.Gene-function studies in systemic lupus erythematosus.Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases.Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts.Human disease phenotypes associated with mutations in TREX1.Monogenic causes of stroke: now and the future.Association of the IRF5 rs2070197 polymorphism with systemic lupus erythematosus: a meta-analysis.TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.Migraine and stroke.The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.Polymorphisms in TREX1 and susceptibility to HIV-1 infection.Update on Vascular Dementia.Intracerebral pseudotumors in a family with cerebroretinal vasculopathy.The genetic dissection of Myo7a gene expression in the retinas of BXD mice.MDA5 and autoimmune disease.A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1.Intracerebral large artery disease in Aicardi-Goutières syndrome implicates SAMHD1 in vascular homeostasis

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P2860

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

http://www.wikidata.org/entity/Q33671295

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2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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name

New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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New roles for the major human 3'-5' exonuclease TREX1 in human disease.

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Aisha Shaikh

http://www.w3.org/2001/XMLSchema#string

Anna Richards

http://www.w3.org/2001/XMLSchema#string

Dirk Spitzer

http://www.w3.org/2001/XMLSchema#string

John P Atkinson

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M Kathryn Liszewski

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Parul H Kothari

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P2860

Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.

Eukaryotic DNA Polymerases

Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes

Rates of spontaneous mutation

Clinical and molecular phenotype of Aicardi-Goutieres syndrome

Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2

Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering

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