Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.
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Potential roles for prions and protein-only inheritance in cancerMoniliophthora perniciosa necrosis- and ethylene-inducing protein 2 (MpNep2) as a metastable dimer in solution: structural and functional implicationsTransient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cellsMisfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.A hypothesis to reconcile the physical and chemical unfolding of proteins.Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products.Heparin binding confers prion stability and impairs its aggregation.Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivationMolecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.Inhibition of TDP-43 aggregation by nucleic acid bindingAmyloid features and neuronal toxicity of mature prion fibrils are highly sensitive to high pressureQuaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.A proteomic approach to obesity and type 2 diabetes.The Volumetric Diversity of Misfolded Prion Protein Oligomers Revealed by Pressure Dissociation.Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes.Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.Allosteric function and dysfunction of the prion protein.The role of RNA in mammalian prion protein conversion.Biomolecular hydration dynamics: a jump model perspective.Thermodynamic and functional characteristics of deep-sea enzymes revealed by pressure effects.Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressorA systematic review of p53 as a biomarker of survival in patients with osteosarcoma.The aggregation of mutant p53 produces prion-like properties in cancer.Eukaryotic aggresomes: from a model of conformational diseases to an emerging type of immobilized biocatalyzers.A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.The "Jekyll and Hyde" Actions of Nucleic Acids on the Prion-like Aggregation of Proteins.Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?Polyanion binding accelerates the formation of stable and low-toxic aggregates of ALS-linked SOD1 mutant A4V.Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseasesMolecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design.Energy landscape of the prion protein helix 1 probed by metadynamics and NMR.Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence.Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.p53 Aggregates penetrate cells and induce the co-aggregation of intracellular p53.Elucidation of stable intermediates in urea-induced unfolding pathway of human carbonic anhydrase IX.Resveratrol prevents p53 aggregation and in breast cancer cells
P2860
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P2860
Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@ast
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@en
type
label
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@ast
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@en
prefLabel
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@ast
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@en
P2093
P2860
P50
P921
P356
P1476
Ligand binding and hydration i ...... p53 tumor suppressor proteins.
@en
P2093
Ana Paula Ano Bom
Daniella Ishimaru
Luis Mauricio T R Lima
Mariana P B Gomes
Monica S Freitas
Tuane C R G Vieira
P2860
P304
P356
10.1021/AR900179T
P407
P577
2010-02-01T00:00:00Z
2010-02-16T00:00:00Z