Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.
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Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisDrug-target residence time: critical information for lead optimization.Extensive in vivo resilience of persistent SalmonellaFabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureusDiscovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Chemical probing of thiotetronate bio-assembly.Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.Conformational adaptation in drug-target interactions and residence time.A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.Substrate recognition by β-ketoacyl-ACP synthases.Design, Synthesis and Biological Evaluation of Some Triazole Schiff's Base Derivatives as Potential Antitubercular Agents.Die Fettsäuresynthese als Angriffspunkt
P2860
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P2860
Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@ast
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@en
type
label
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@ast
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@en
prefLabel
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@ast
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@en
P2093
P2860
P356
P1476
Slow onset inhibition of bacte ...... n synthases by thiolactomycin.
@en
P2093
Bela Ruzsicska
Carl A Machutta
Carlos Simmerling
Caroline Kisker
Gopal R Bommineni
Kanishk Kapilashrami
Peter J Tonge
Sylvia R Luckner
P2860
P304
P356
10.1074/JBC.M109.077909
P407
P577
2009-12-16T00:00:00Z