Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
about
EGF receptor ligands: recent advancesRhomboids, signalling and cell biologyPhosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.iRhoms; Its Functions and Essential Roles.MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin.Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosisAlternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse.Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle.MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin.iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
P2860
Q28066531-ECD7C553-D318-4185-8846-A2BE9AD6F3BEQ28070034-A7321034-1B4E-47ED-AD58-7C0BD33AEC82Q33704501-89AB4D98-2F80-455C-BB63-05EAF989B80BQ36640392-5890F43E-05ED-4AF5-A53D-59585F0F307FQ37268998-772CB39A-16F4-41FC-AD55-E2DB6B1660D2Q38706195-1D446267-B296-4872-A27D-656FBD68A4D8Q38749991-9862B3AE-83FB-4BFA-BDE6-B1FDB24AFFCDQ38822173-BDDE5680-26CF-4747-BD37-EDF50C3FC2FFQ42615354-1F7A78AE-598B-4D01-A383-CF90AEF0F098Q46799374-259B3AF8-E60C-445C-89AE-0434A2D1D413Q47312702-F4CF94E8-65D8-4E8C-B811-4344EFB71F2BQ51107995-09FFDBD9-4ABC-40EC-9434-99FF68365268Q51653461-DF3247F5-2115-467A-8E8F-3871089FF5C1Q51689102-B7FDFA61-DB50-45F3-9811-CCE4C2F506E4Q53831425-CC8C3489-E7FD-49F4-BD87-CDE8130C1B5AQ55711821-DAC5F00D-2577-45DF-89DA-C357B12352D3Q56889930-544D5CB0-98A7-45B8-BBE0-658AC8AA0926
P2860
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@ast
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@en
type
label
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@ast
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@en
prefLabel
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@ast
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@en
P2093
P2860
P356
P1476
Rhbdf2 mutations increase its ...... ced secretion of amphiregulin.
@en
P2093
Kenneth R Johnson
Leonard D Shultz
Lisa M Burzenski
Richard S Maser
Timothy M Stearns
Vishnu Hosur
P2860
P304
P356
10.1073/PNAS.1323908111
P407
P577
2014-05-13T00:00:00Z