Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.
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Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy.Nitric oxide and mitochondria in metabolic syndrome.Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolismSirtuins, aging, and cardiovascular risks.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancerOver-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway.Prevention of the development of heart failure with preserved ejection fraction by the phosphodiesterase-5A inhibitor vardenafil in rats with type 2 diabetes.Erectile dysfunction and its management in patients with diabetes mellitus.Influence of the PDE5 inhibitor tadalafil on redox status and antioxidant defense system in C2C12 skeletal muscle cells.A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice.Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure.PDE5 Inhibitor Tadalafil and Hydroxychloroquine Cotreatment Provides Synergistic Protection against Type 2 Diabetes and Myocardial Infarction in Mice.Tadalafil, a long acting phosphodiesterase inhibitor, promotes bone marrow stem cell survival and their homing into ischemic myocardium for cardiac repair.Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial hypertension.Concomitant Phosphodiesterase 5 Inhibition Enhances Myocardial Protection by Inhaled Nitric Oxide in Ischemia-Reperfusion Injury.Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin.Sildenafil ameliorates right ventricular early molecular derangement during left ventricular pressure overload.
P2860
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P2860
Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.
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2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@ast
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@en
type
label
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@ast
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@en
prefLabel
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@ast
Chronic inhibition of phosphod ...... of NO/SIRT1/PGC-1α signaling.
@en
P2093
P2860
P1476
Chronic inhibition of phosphod ...... e of NO/SIRT1/PGC-1α signaling
@en
P2093
Edward J Lesnefsky
Rakesh C Kukreja
Saisudha Koka
P2860
P304
P356
10.1152/AJPHEART.00865.2013
P577
2014-04-11T00:00:00Z