The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?
about
Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase.The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKRAntiviral actions of interferonsModular structure of PACT: distinct domains for binding and activating PKRAntiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinaseNoncytopathic Bovine Viral Diarrhea Virus Inhibits Double-Stranded RNA-Induced Apoptosis and Interferon SynthesisMechanisms of Interferon-alpha induced apoptosis in malignant cellsThe direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formationInteraction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neuronsActivation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neuronsInhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA constructTranslational control of viral gene expression in eukaryotesActivation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK)Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells.Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunityThe protein kinase PKR: a molecular clock that sequentially activates survival and death programs.Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells.Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I InterferonProtein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infectionStraightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR.Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection.Role of apoptosis and cytokines in influenza virus morbidity.Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trialControl of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication.Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells.A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection.Double-stranded RNA activates a p38 MAPK-dependent cell survival program in biliary epithelia.The epizootic haematopoietic necrosis virus (Iridoviridae) induces apoptosis in vitro.Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells.Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells.Mutations in the M-gene segment can substantially increase replication efficiency of NS1 deletion influenza A virus in MDCK cells.Downregulation of Bcl-2 sensitises interferon-resistant renal cancer cells to Fas.Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein.Pharmacokinetics and enhanced PKR response in patients with chronic hepatitis C treated with pegylated interferon alpha-2b and ribavirin.Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.
P2860
Q24290751-06A21F3F-8B40-4BCA-92C8-5F8344540F4CQ24540098-7DA3C214-AC2F-4255-91FA-C1728690ECD9Q24550676-CA3B9DFA-304C-4D45-9EBA-BAD921AD8E14Q24551001-4F1B2C30-3C78-46AC-99BA-0A9F11E8196BQ27469720-D5F5CAD8-9E39-4B4C-AC9E-67A6EAD5764FQ27469798-FF49AF6A-1DFC-4319-B1B7-1E0E8FE4242BQ28202091-12EE1799-A50A-4718-9FFA-34B3C5C2ED23Q28215791-E67407E3-CAB8-40EC-AC4D-269D2EC11354Q28304609-87C00517-6659-4266-A92C-E2B2691308CFQ28577883-04BD16DF-B7DE-45DB-9DFF-4A8B87F61FB6Q33822538-043C65AC-670E-4465-AAFF-B100E942CB75Q33935121-F70A092A-80B0-4E3A-A2BF-93405A664A76Q33954924-46285B64-81C9-4EF5-A603-F3A2F912076CQ33958542-F7DF092B-30A9-4680-B372-FE742D719D74Q33964325-22A5D629-A49B-4D1A-8B16-3C9BE5413AF4Q34046869-42F73E7A-92F1-40C0-BED6-F010B34BFA5DQ34107642-617D4FFF-8DD7-4B7C-937E-918E4E9890F5Q34192731-FD1808FC-C6C9-464F-AE7E-960871CEA897Q34978491-E6DB66B6-160E-4693-ABDD-E9B54DBFEF69Q35557650-259F07A3-CD08-43B4-BB09-4279741947E6Q35598219-84C33F26-EEBF-4275-81E7-DC5FC3E6449BQ35837330-FEDE287C-05F2-436E-89D8-42166D5B5882Q36145616-CE6013C4-F3A3-4423-AA5E-D446AE38FF97Q36231177-DD862DBB-0000-4E45-93D0-799C5C63589FQ37217280-AE3E1CBF-19B4-41B1-9FDB-5AEEFED0302FQ37277545-720CF88A-CF0E-45BC-BD20-0DC396D79E30Q39683981-3FE5203D-CEE0-4534-9C34-A673C5116C42Q39755419-E5FEA1A3-748B-43CA-87A8-E3C5F4FDA2DFQ40430436-46B7F269-07D4-4D3B-A638-1AA8928BE376Q40530820-CD973F22-6949-422D-92F4-FF2ABFDE6E78Q40675697-6EE585EB-DE7C-4589-BB3C-6D1D93C1BAD7Q40742731-2FBBA446-79E1-4446-B8AD-3389ED87234CQ40758298-B01A42A7-5DA9-4D64-AFCD-C16F4800FD13Q40866646-DC08106A-2B80-4C46-95ED-3F5DF5AF913FQ41573715-7DE3C6E3-542D-46E5-ABD5-6311B5026424Q42143671-586A5868-EC55-4712-B920-A47491EF9209Q43034820-DD13E548-E694-44EB-AC05-01B1A766F092Q43037733-F20F8437-AD1D-4313-A82C-0246FB4EA25FQ43517016-1812A146-522B-43F0-BB1C-C0A1161CC545Q43559384-3C25881A-470A-4F0B-B3B9-F3D8ABB62FB4
P2860
The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The emerging role of the inter ...... effector: a new face of death?
@ast
The emerging role of the inter ...... effector: a new face of death?
@en
type
label
The emerging role of the inter ...... effector: a new face of death?
@ast
The emerging role of the inter ...... effector: a new face of death?
@en
prefLabel
The emerging role of the inter ...... effector: a new face of death?
@ast
The emerging role of the inter ...... effector: a new face of death?
@en
P356
P1476
The emerging role of the inter ...... effector: a new face of death?
@en
P304
P356
10.1089/107999099313677
P577
1999-06-01T00:00:00Z