Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo.
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mRNA trans-splicing in gene therapy for genetic diseasesEmerging Role of miRNAs in the Drug Resistance of Gastric CancerMicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic ConsiderationsAdeno-associated virus-mediated microRNA delivery and therapeuticsThe unstable repeats--three evolving faces of neurological diseaseCurrent prospects for RNA interference-based therapiesConstruction of permanently inducible miRNA-based expression vectors using site-specific recombinasesTargeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNAExpression of multiple artificial microRNAs from a chicken miRNA126-based lentiviral vectorRNA and diseaseImproved knockdown from artificial microRNAs in an enhanced miR-155 backbone: a designer's guide to potent multi-target RNAiArgonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liverAllele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Zinc-finger-based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa.An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype.Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous systemA microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICERSequence-non-specific effects of RNA interference triggers and microRNA regulators.Viral envelope protein 53R gene highly specific silencing and iridovirus resistance in fish Cells by AmiRNA.Expression of RNA interference triggers from an oncolytic herpes simplex virus results in specific silencing in tumour cells in vitro and tumours in vivo.Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.The potential clinical applications and prospects of microRNAs in lung cancerInfluence of immune responses in gene/stem cell therapies for muscular dystrophies.Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brainA miR-21 hairpin structure-based gene knockdown vector.Gene networks and the neuroendocrine regulation of pubertyBipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene.Gamma-retroviral vector design for the co-expression of artificial microRNAs and therapeutic proteins.RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors.Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo.Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate modelOptimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100.Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapysiSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction.Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.
P2860
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P2860
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@ast
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@en
type
label
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@ast
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@en
prefLabel
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@ast
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@en
P2860
P356
P1433
P1476
Artificial microRNAs as siRNA ...... o shRNAs in vitro and in vivo.
@en
P2093
Beverly L Davidson
Inês Martins
P2860
P304
P356
10.1038/MT.2008.231
P577
2008-11-11T00:00:00Z