Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element. - Wikidata - wikimedia - TriplyDB

Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.

Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.

http://www.wikidata.org/entity/Q33713427

about

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia Current and future alternative therapies for beta-thalassemia major Progresses towards safe and efficient gene therapy vectors Hematopoietic stem cell engineering at a crossroads Posttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma gene Direct identification of insulator components by insertional chromatin immunoprecipitation Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.Eukaryotic systems broaden the scope of synthetic biology.Future alternative therapies for β-thalassemia.Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease.Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.Prolonged survival and phenotypic correction of Akp2(-/-) hypophosphatasia mice by lentiviral gene therapy.Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.The new self-inactivating lentiviral vector for thalassemia gene therapy combining two HPFH activating elements corrects human thalassemic hematopoietic stem cells.Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.Correction of beta-thalassemia major by gene transfer in haematopoietic progenitors of pediatric patients.Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.Supplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells.Physiological and tissue-specific vectors for treatment of inherited diseases.The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors Gene therapy in thalassemia and hemoglobinopathies.Chromatin insulator elements: establishing barriers to set heterochromatin boundaries.Recent advances in gene therapy for thalassemia.Development of gene therapy for thalassemia.Biosafety features of lentiviral vectors New developments in lentiviral vector design, production and purification.A self-deletion lentiviral vector to reduce the risk of replication-competent virus formation.Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins.Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector Insulated Foamy Viral Vectors.The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia.The Use of Transcription Terminators to Generate Transgenic Lines of Chinese Hamster Ovary Cells (CHO) with Stable and High Level of Reporter Gene Expression.Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors.The cytochrome c gene proximal enhancer drives activity-dependent reporter gene expression in hippocampal neurons.Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application.

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P2860

Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.

http://www.wikidata.org/entity/Q33713427

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Optimized lentiviral vector de ...... n locus HS4 insulator element.

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Optimized lentiviral vector de ...... n locus HS4 insulator element.

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Molecular Therapy

P1476

Optimized lentiviral vector de ...... n locus HS4 insulator element.

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P2093

Derek A Persons

http://www.w3.org/2001/XMLSchema#string

Hideki Hanawa

http://www.w3.org/2001/XMLSchema#string

Huifen Zhao

http://www.w3.org/2001/XMLSchema#string

Motoko Yamamoto

http://www.w3.org/2001/XMLSchema#string

Takashi Shimada

http://www.w3.org/2001/XMLSchema#string

P2860

Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat

Mfold web server for nucleic acid folding and hybridization prediction

The insulation of genes from external enhancers and silencing chromatin.

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

Insulators: exploiting transcriptional and epigenetic mechanisms

Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities.

Side effects of retroviral gene transfer into hematopoietic stem cells.

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667-674

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10.1038/MT.2009.1

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4

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17

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2009-02-17T00:00:00Z

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24021835

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19223867

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2835111

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