HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein. - Wikidata - wikimedia - TriplyDB

HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein.

HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein.

http://www.wikidata.org/entity/Q33717131

about

Mechanisms of drug resistance in colon cancer and its therapeutic strategies The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.Molecular mechanisms of hypoxia in cancer.MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.F-18 fluoromisonidazole for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy Knockdown of autophagy-related gene LC3 enhances the sensitivity of HepG2 cells to epirubicin Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer.MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs.MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1 Role of miR-27a, miR-181a and miR-20b in gastric cancer hypoxia-induced chemoresistance.Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α.TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer.Tariquidar sensitizes multiple myeloma cells to proteasome inhibitors via reduction of hypoxia-induced P-gp-mediated drug resistance.Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma.Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients.Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia.Sorafenib reverses resistance of gastric cancer to treatment by cisplatin through down-regulating MDR1 expression.Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity?Effect of Y6, an epigallocatechin gallate derivative, on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells.Correlation between liver cancer pain and the HIF-1 and VEGF expression levels.Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions.Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression.Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer.Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes.Impaired pentose phosphate pathway in the development of 3D MCF-7 cells mediated intracellular redox disturbance and multi-cellular resistance without drug induction.Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway.Co-delivery of hypoxia inducible factor-1α small interfering RNA and 5-fluorouracil to overcome drug resistance in gastric cancer SGC-7901 cells.Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status.Correlation between TAP detection and common digestive tract precancerous lesions.Glioblastoma Stem Cells and Their Microenvironment.Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway.

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HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein.

http://www.wikidata.org/entity/Q33717131

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2014年の論文

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HIF-1α inhibition reverses mul ...... lation of MDR1/P-glycoprotein.

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Feng Pan

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Houjie Liang

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Jianfang Chen

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Jianjun Li

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Lan Zou

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Yanling Zhang

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Yonghai Peng

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Zhenyu Ding

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P2860

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies.

Multicellular resistance: a paradigm for clinical resistance?

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.

Tumor hypoxia in cancer therapy.

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects

Drug resistance and the microenvironment: nature and nurture.

Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment

Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.

Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo.

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262885869

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24901645

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multiple drug resistance

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