T-bet, a Th1 transcription factor regulates the expression of Tim-3. - Wikidata - wikimedia - TriplyDB

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

http://www.wikidata.org/entity/Q33721890

about

Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators Tim-3 and its role in regulating anti-tumor immunity.Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection.Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases.Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells.Tregs and infections: on the potential value of modifying their function.IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma.Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9 T Cell Immunoglobulin Mucin Domain (TIM)-3 Promoter Activity in a Human Mast Cell Line.The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis Transcriptome signature for dampened Th2 dominance in acellular pertussis vaccine-induced CD4(+) T cell responses through TLR4 ligation.Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients.TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.Galectin-9 regulates T helper cell function independently of Tim-3.The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.Upregulation of T-cell Immunoglobulin and Mucin-Domain Containing-3 (Tim-3) in Monocytes/Macrophages Associates with Gastric Cancer Progression.Functional exhaustion of CD4+ T cells induced by co-stimulatory signals from myeloid leukaemia cells.T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection.The Clinical Significance of Abnormal Tim-3 Expression on NK Cells from Patients with Gastric Cancer.MicroRNA-155 regulates interferon-γ production in natural killer cells via Tim-3 signalling in chronic hepatitis C virus infection.T cell exhaustion: from pathophysiological basics to tumor immunotherapy.Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.Transcriptional and epigenetic regulation of T cell hyporesponsiveness.c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor.DNA demethylation of the TIM-3 promoter is critical for its stable expression on T cells.Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.Tim-3 pathway controls regulatory and effector T cell balance during hepatitis C virus infection.Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease.Acute Stimulation Generates Tim-3-expressing Th1-type CD4 T Cells That Persist In Vivo and Show Enhanced Effector Function.PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer.Tim-3, Lag-3, and TIGIT.Imbalanced expression of T-bet and T cell immunoglobulin mucin-3 in patients with aplastic anaemia.Immune regulation by Tim-3.

P2860

Q26782799-DF6D1570-CCB0-4EB9-9CD2-7989B7DDEDC6 Q33909020-A7ADD984-8825-417D-BF95-1A8BDBFBD122 Q34335966-7C7206FD-36C2-4DB7-B7EE-29D0A4C35929 Q34514517-9AC2A4D1-B9D6-42BA-90E8-324DE0C0968F Q34648954-9AFA02F7-68C7-4389-9FA6-35E48EFB232D Q34965205-3FF73ACF-9013-4BA0-9774-3DB262D619A6 Q35031602-A97B3AF9-79EA-4B3E-B35A-B71EDEB57083 Q35178738-D0793A73-347E-475E-B410-ACB13E3AB20F Q35461764-08DF2613-DF2D-41E7-B362-45DCE3654ED6 Q35609371-D560F543-0460-4B27-B2F2-B690EA34E3E8 Q35858092-81BEBC82-2E42-46D8-B6B7-A4161F25EE42 Q35876978-D140CDA9-4E14-48DF-B5FE-987EACFE61C2 Q36431024-3F77070B-AB64-4878-8BBC-B26CCB0AA710 Q36451717-B265B6E8-D360-415D-9C91-D0259B6088D6 Q36841068-A637D127-31A3-4646-84F8-9833DE7CEBBE Q36919711-E288B755-A9B3-49F1-8166-A3D0DB80EF78 Q37536649-341B77D4-23CF-4F24-8BD0-0497D9E192FB Q37763998-2FD87399-78D4-4992-B758-94FAA70F1A11 Q38316374-445FA783-DD5E-48CC-BCEB-09C84C00BB32 Q38445342-4974AF05-A995-4ACC-B5BD-B4CA3DE24770 Q38636569-AC16577D-1950-457C-9E29-3A7761DC88DC Q38727915-C6268D86-FB6E-4B19-9770-96289273A5D9 Q38733598-121AED1D-17AB-435C-BA70-6F8A810CC41D Q38733708-B8B7B4E7-A5B5-49E6-91AD-14F54BE4CFBD Q38848984-15772FA2-2405-42D1-9CC8-5DFB250D1C1D Q38899741-26025540-D309-4602-83C3-F2FACE9B2366 Q39078341-5D4BC6D3-03BF-4EEE-BEFE-D1F4823DBACA Q39160992-4D3FA3BB-E04E-482A-994E-DC56BB33FECB Q39367810-5337C95F-BFF3-416C-964A-C18045E1B426 Q39579445-2AF5CE09-D168-438E-A953-C00B530BB181 Q39987703-BCAAC559-89C6-4ABD-B7F9-15DBBAD9CE4F Q41825142-813680CA-C5EE-4374-AFE0-38E294629AEB Q42071282-9283CCD3-8E49-40A5-BD25-772380095CC0 Q42240174-C2C27CC4-C794-468D-98A5-97D9A57A8C31 Q44027824-60E7BE46-6C08-431F-B576-B3BCEC947DB7 Q47556597-8D506641-602A-4C7F-AC24-A117C3FF7ECB Q47806987-378EABB6-78B4-4F8A-A075-792C5199FAC7 Q50125564-78E44FFC-9889-484B-AFA4-A388AD807378 Q51836916-2B07FA45-B85B-45C1-97A7-F0DCF2C77854 Q52348457-10B26C35-BE8E-4844-A27D-85024711BBBE

P2860

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

http://www.wikidata.org/entity/Q33721890

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@ast

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@en

type

label

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@ast

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@en

prefLabel

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@ast

T-bet, a Th1 transcription factor regulates the expression of Tim-3.

@en

P1433

Q33721890-7E784DD2-F154-4412-8A4E-8402D2F0A9D2

P1476

Q33721890-F4BC4822-E3FD-438D-8FED-FF4602FAFEEE

P2093

Q33721890-48D914AB-F152-4510-A588-C40EA1E8DE70

Q33721890-4DD7B51C-E630-4C46-AFFF-78B5CD503DF6

Q33721890-A2DD3663-00F4-42A9-BF98-09513124E73B

Q33721890-C44BAF21-14C7-413C-AF9C-7A0A5AB886C6

Q33721890-DE1AECB8-1E9A-47D8-AE3D-4EF741DA72BF

Q33721890-E72E076C-3BA9-4A55-B1E9-C00BC27A655F

P2860

Q33721890-0255A728-3208-42CE-9FB9-E9C1DB48678D

Q33721890-13609D93-A78D-4C18-8CD0-C33530CA8960

Q33721890-16DAEA74-0AD1-4DFC-B84A-A023821AF0D4

Q33721890-22054376-F04D-4D82-9123-8FD5CDBBFD3A

Q33721890-22CCD84C-0D50-4C73-8EC5-269B0AC44662

Q33721890-2B9476E1-273C-480C-99A0-8882352D2261

Q33721890-47FCEBC3-B99B-4BC6-8A8D-2D711905C490

Q33721890-4BFB3132-F793-44B2-A68C-097C0159E1A6

Q33721890-4F229E17-51D4-4AE3-A4E6-3D04D2EEBF33

Q33721890-6283839A-DC3B-4EA5-9FD0-C1704FD0532A

P304

Q33721890-EAB99D8D-0E9B-4F67-B9CC-F515B28787C0

P31

Q33721890-79358E12-63F8-4CC6-A672-F891D083E51F

P356

Q33721890-F133B35F-68F9-418D-B0FF-EAE34FDA0CEC

P407

Q33721890-A26DEAAA-7C63-487A-9EA2-978AB4A4158B

P433

Q33721890-AC181D6C-63E5-4B1B-AF89-365C783066A2

P478

Q33721890-1B0A464C-72E8-483C-BFF1-194D69ABFD09

P50

Q33721890-54217BFD-BFC0-4697-9D50-D9CE6A05BE42

P577

Q33721890-292C8694-CAF1-474A-BD73-0E5F726D07B3

P5875

Q33721890-C569F132-99D4-4C52-B791-603AA8CAB0ED

P698

Q33721890-522438EC-FF31-425F-ACC3-3EAB67419522

P932

Q33721890-8E9D0885-DA44-45F4-BB39-5851AA9BE579

P356

P1433

European Journal of Immunology

P1476

T-bet, a Th1 transcription factor regulates the expression of Tim-3

@en

P2093

Ana C Anderson

http://www.w3.org/2001/XMLSchema#string

Catherine A Sabatos-Peyton

http://www.w3.org/2001/XMLSchema#string

David H Lee

http://www.w3.org/2001/XMLSchema#string

Laurie H Glimcher

http://www.w3.org/2001/XMLSchema#string

Valerie Dardalhon

http://www.w3.org/2001/XMLSchema#string

Vijay K Kuchroo

http://www.w3.org/2001/XMLSchema#string

P2860

A novel transcription factor, T-bet, directs Th1 lineage commitment

Dysregulated T cell expression of TIM3 in multiple sclerosis

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells

Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9

Lack of TIM-3 immunoregulation in multiple sclerosis

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

P304

859-866

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/EJI.200939842

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

40

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40848736

http://www.w3.org/2001/XMLSchema#string

P698

20049876

http://www.w3.org/2001/XMLSchema#string

P932

2837127

http://www.w3.org/2001/XMLSchema#string