Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
about
Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injurySulfonate-containing thiiranes as selective gelatinase inhibitors.Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT.QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue.Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinasesEndogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.Selective water-soluble gelatinase inhibitor prodrugs.Structure-Activity Relationship for Thiirane-Based Gelatinase InhibitorsSelective gelatinase inhibitor neuroprotective agents cross the blood-brain barrierAcceleration of diabetic wound healing using a novel protease-anti-protease combination therapy.Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.A chemical biological strategy to facilitate diabetic wound healing.Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.Controlling toxicity of Peptide-drug conjugates by different chemical linker structures.The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination.Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer.Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice.
P2860
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P2860
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@ast
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@en
type
label
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@ast
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@en
prefLabel
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@ast
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@en
P2093
P2860
P1476
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
@en
P2093
Christopher Forbes
Jed F Fisher
Leticia I Llarrull
Marta Toth
Michael Gossing
Mijoon Lee
Rafael Fridman
Shahriar Mobashery
P2860
P304
P356
10.1111/J.1747-0285.2009.00881.X
P50
P577
2009-10-06T00:00:00Z