High-resolution structure of infectious prion protein: the final frontier
about
β-hairpin-mediated formation of structurally distinct multimers of neurotoxic prion peptidesTransgenic Rabbits Expressing Ovine PrP Are Susceptible to ScrapieEx vivo mammalian prions are formed of paired double helical prion protein fibrils.Interdomain contacts control folding of transcription factor RfaH.Human prion diseases: surgical lessons learned from iatrogenic prion transmissionVirtual screening on an α-helix to β-strand switchable region of the FGFR2 extracellular domain revealed positive and negative modulators.Attachment of pathogenic prion protein to model oxide surfaces.The structure of the infectious prion protein: experimental data and molecular models.Prion propagation can occur in a prokaryote and requires the ClpB chaperone.Structure-based drug design identifies polythiophenes as antiprion compounds.Two misfolding routes for the prion protein around pH 4.5.Inhibition of TDP-43 aggregation by nucleic acid bindingQuaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape.Helices 2 and 3 are the initiation sites in the PrP(C) → PrP(SC) transitionSingle-molecule approaches to prion protein misfoldingComparing the energy landscapes for native folding and aggregation of PrP.Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification.Amyloid fibrils from the N-terminal prion protein fragment are infectious.The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentrationDivergent prion strain evolution driven by PrPC expression level in transgenic mice.Mechanical Deformation Mechanisms and Properties of Prion Fibrils Probed by Atomistic Simulations.The structure of human prions: from biology to structural models-considerations and pitfalls.Evaluation of infective property of recombinant prion protein amyloids in cultured cells overexpressing cellular prion protein.Mammalian prions and their wider relevance in neurodegenerative diseases.Mammalian prion amyloid formation in bacteria.Prion strains in mammals: Different conformations leading to disease.Synthesis of double-fluorescent labeled prion protein for FRET analysis.Determination of amyloid core structure using chemical shifts.Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.Proteolysis of abnormal prion protein with a thermostable protease from Thermococcus kodakarensis KOD1.Left-handed polyproline-II helix revisited: proteins causing proteopathies.Mammalian amyloidogenic proteins promote prion nucleation in yeast.Perturbations in inter-domain associations may trigger the onset of pathogenic transformations in PrP(C): insights from atomistic simulations.β-sheet-like formation during the mechanical unfolding of prion protein.The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof.Following the aggregation of human prion protein on Au(111) surface in real-time.
P2860
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P2860
High-resolution structure of infectious prion protein: the final frontier
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
High-resolution structure of infectious prion protein: the final frontier
@ast
High-resolution structure of infectious prion protein: the final frontier
@en
type
label
High-resolution structure of infectious prion protein: the final frontier
@ast
High-resolution structure of infectious prion protein: the final frontier
@en
prefLabel
High-resolution structure of infectious prion protein: the final frontier
@ast
High-resolution structure of infectious prion protein: the final frontier
@en
P2860
P356
P1476
High-resolution structure of infectious prion protein: the final frontier
@en
P2093
Claudio Soto
Rodrigo Diaz-Espinoza
P2860
P2888
P304
P356
10.1038/NSMB.2266
P577
2012-04-04T00:00:00Z