RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. - Wikidata - wikimedia - TriplyDB

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

http://www.wikidata.org/entity/Q33728908

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Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1.Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice.Neuroinflammation as modifier of genetically caused neurological disorders of the central nervous system: Understanding pathogenesis and chances for treatment.The in vivo evidence for regulated necrosis.RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.Mechanisms of RIPK3-induced inflammation.Roles of Caspases in Necrotic Cell Death.Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.The Contribution of Necroptosis in Neurodegenerative Diseases.Necroptosis and Cancer.Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.RIPK3 in cell death and inflammation: the good, the bad, and the ugly.Ferroptosis: bug or feature?Necroptosis in neurodegenerative diseases: a potential therapeutic target.Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications.Oxidized low-density lipoprotein induced mouse hippocampal HT-22 cell damage via promoting the shift from autophagy to apoptosis.CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens.ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.Necroptosis activation in Alzheimer's disease.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.miRNA-21 ablation protects against liver injury and necroptosis in cholestasis.Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons.RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP.Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.CNS inflammation and neurodegeneration.Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis.Optineurin Functions for Optimal Immunity.Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression.MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.Necroptosis in development and diseases.

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P2860

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

http://www.wikidata.org/entity/Q33728908

description

2016 nî lūn-bûn

@nan

2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2016年の論文

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2016年論文

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2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

name

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@ast

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@en

type

label

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@ast

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@en

prefLabel

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@ast

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

@en

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SCIENCE.AAF6803

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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

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Adnan Kasim Mookhtiar

http://www.w3.org/2001/XMLSchema#string

Amanda Tomie Ouchida

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Dimitry Ofengeim

http://www.w3.org/2001/XMLSchema#string

Jian-bing Fan

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Jiefei Geng

http://www.w3.org/2001/XMLSchema#string

John Ravits

http://www.w3.org/2001/XMLSchema#string

Judy Park DeWitt

http://www.w3.org/2001/XMLSchema#string

Junichi Hitomi

http://www.w3.org/2001/XMLSchema#string

Junying Yuan

http://www.w3.org/2001/XMLSchema#string

Marcus Florez

http://www.w3.org/2001/XMLSchema#string

P2860

WGCNA: an R package for weighted correlation network analysis

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Axon degeneration: Molecular mechanisms of a self-destruction pathway

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603-608

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scholarly article

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10.1126/SCIENCE.AAF6803

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P433

6299

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353

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Manolis Pasparakis

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2016-08-01T00:00:00Z

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27493188

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amyotrophic lateral sclerosis

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5444917

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