Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
about
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinomaHistone demethylase LSD1 controls the phenotypic plasticity of cancer cellsSLUG: Critical regulator of epithelial cell identity in breast development and cancerKDM1 class flavin-dependent protein lysine demethylasesThe WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineageActivation of KRAS promotes the mesenchymal features of basal-type breast cancer.RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development.ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition ProgramThe origin of breast tumor heterogeneity.Cell Fate Decisions During Breast Cancer Development.The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer.Cancer cells exhibit clonal diversity in phenotypic plasticity.Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cellsMicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis.The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells.IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion.A novel slug-containing negative-feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal.Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma.Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis.Human NUMB6 Induces Epithelial-Mesenchymal Transition and Enhances Breast Cancer Cells Migration and Invasion.EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.
P2860
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P2860
Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Cell-state transitions regulat ...... eneration and tumor initiation
@ast
Cell-state transitions regulat ...... eneration and tumor initiation
@en
type
label
Cell-state transitions regulat ...... eneration and tumor initiation
@ast
Cell-state transitions regulat ...... eneration and tumor initiation
@en
prefLabel
Cell-state transitions regulat ...... eneration and tumor initiation
@ast
Cell-state transitions regulat ...... eneration and tumor initiation
@en
P2093
P2860
P1433
P1476
Cell-state transitions regulat ...... eneration and tumor initiation
@en
P2093
Adam Skibinski
Ania Wronski
Charlotte Kuperwasser
Grace Gill
Maja Sedic
Piyush B Gupta
Sarah Phillips
Sohini Mazumdar
Stephanie H Shirley
Theresa Proia
P2860
P304
P356
10.1016/J.STEMCR.2014.03.008
P577
2014-04-24T00:00:00Z