Serine racemase deletion protects against cerebral ischemia and excitotoxicity. - Wikidata - wikimedia - TriplyDB

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

http://www.wikidata.org/entity/Q33738332

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The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS)Serine racemase: a key player in apoptosis and necrosis Increased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia.Roles of NFκB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization.Heterogeneity of D-Serine Distribution in the Human Central Nervous System.The postnatal development of D-serine in the retinas of two mouse strains, including a mutant mouse with a deficiency in D-amino acid oxidase and a serine racemase knockout mouse Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.d-serine levels in Alzheimer's disease: implications for novel biomarker development The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms.Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.D-amino acid oxidase controls motoneuron degeneration through D-serine.Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies.Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.D-serine as a gliotransmitter and its roles in brain development and disease.TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.Controlling reaction specificity in pyridoxal phosphate enzymes.D-Serine: a key to synaptic plasticity?Serine racemase: an unconventional enzyme for an unconventional transmitter.NMDA receptor activation: two targets for two co-agonists.Protein interacting with C kinase and neurological disorders.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.AMPA receptor mediated D-serine release from retinal glial cells.Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.ATP binding to human serine racemase is cooperative and modulated by glycine.Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis.Biochemical Properties of Human D-Amino Acid Oxidase.Insulin treatment prevents the increase in D-serine in hippocampal CA1 area of diabetic rats.Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy.Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.The Role of Serine Racemase in the Pathophysiology of Brain Disorders.Regulation of human serine racemase activity and dynamics by halides, ATP and malonate Emerging Role of D-Amino Acid Metabolism in the Innate Defense.

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P2860

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

http://www.wikidata.org/entity/Q33738332

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@ast

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@en

type

label

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@ast

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@en

prefLabel

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@ast

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@en

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JNEUROSCI.4297-09.2010

P1433

Journal of Neuroscience

P1476

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

@en

P2093

Abdullah S Ahmad

http://www.w3.org/2001/XMLSchema#string

Asif K Mustafa

http://www.w3.org/2001/XMLSchema#string

Emil Zeynalov

http://www.w3.org/2001/XMLSchema#string

Gautam Sikka

http://www.w3.org/2001/XMLSchema#string

Jeffrey T Ehmsen

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Joseph T Coyle

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Roxanne K Barrow

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Sadia K Gazi

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Sylvain Doré

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P2860

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation

Protein S-nitrosylation: purview and parameters

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.

Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

D-serine regulation of NMDA receptor activity.

Blocking NO synthesis: how, where and why?

Cell signaling and neuronal death.

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1413-1416

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scholarly article

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10.1523/JNEUROSCI.4297-09.2010

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4

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30

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Solomon Halbert Snyder

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2010-01-01T00:00:00Z

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20107067

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cerebral infarction

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2841469

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