p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.

p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.

Item
http://www.wikidata.org/entity/Q33747925
Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria.Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancerMitochondrial longevity pathwaysSuppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membraneArginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerabilitySrc tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity.p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress.Cellular functions regulated by phosphorylation of EGFR on Tyr845.Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway.p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1.Heritable, allele-specific chromosomal looping between tandem promoters specifies promoter usage of SHC1.Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of Ephrin tyrosine kinase evolution.
P2860

p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.

Item
http://www.wikidata.org/entity/Q33747925
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@ast
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@en
type
label
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@ast
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@en
prefLabel
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@ast
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
p66shc inhibits insulin-like g ...... ment of Src kinase activation.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932