Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting
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Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?You eat what you are: autophagy inhibition as a therapeutic strategy in leukemiaMatrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells.Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia.Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression.Targeting the mTOR Pathway in Leukemia.Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase.The role of autophagy in the cross-talk between epithelial-mesenchymal transitioned tumor cells and cancer stem-like cells.Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia.NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells.Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia.Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma.High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma.Targeting autophagy in cancer.Autophagy inhibition sensitizes LY3023414-induced anti-glioma cell activity in vitro and in vivo.CD24 regulates sorafenib resistance via activating autophagy in hepatocellular carcinoma.Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2.The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought
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P2860
Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting
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2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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name
Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@ast
Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@en
type
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Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@ast
Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@en
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Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@ast
Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@en
P2093
P2860
P1476
Autophagy is a survival mechan ...... g dual mTORC2/mTORC1 targeting
@en
P2093
Amy Szilard
Antonella Sassano
Dennis J Goussetis
Elias Gounaris
Elizabeth A Eklund
Elspeth M Beauchamp
Francis J Giles
Jessica K Altman
Leonidas C Platanias
Marco Colamonici
P2860
P304
P356
10.1158/1078-0432.CCR-13-3218
P407
P577
2014-03-07T00:00:00Z