Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. - Wikidata - wikimedia - TriplyDB

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

http://www.wikidata.org/entity/Q33754509

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FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.Turnover of amyloid precursor protein family members determines their nuclear signaling capability Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.δ-COP modulates Aβ peptide formation via retrograde trafficking of APP Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.Pharmacological targeting of the β-amyloid precursor protein intracellular domain.An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.Biology and pathophysiology of the amyloid precursor protein.APP physiological and pathophysiological functions: insights from animal models.Functions of the APP gene family in the nervous system: insights from mouse models.The role of inflammatory processes in Alzheimer's disease.Fe65 matters: new light on an old molecule.Redundancy and divergence in the amyloid precursor protein family.Not just amyloid: physiological functions of the amyloid precursor protein family.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease?Paradoxical effect of TrkA inhibition in Alzheimer's disease models.Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.Fe65 Ser228 is phosphorylated by ATM/ATR and inhibits Fe65-APP-mediated gene transcription.A role for APP in Wnt signalling links synapse loss with β-amyloid production

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Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

http://www.wikidata.org/entity/Q33754509

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Tyr(682) in the intracellular ...... ogenic APP processing in vivo.

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Tyr(682) in the intracellular ...... ogenic APP processing in vivo.

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Tyr(682) in the intracellular ...... ogenic APP processing in vivo.

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Tyr(682) in the intracellular ...... ogenic APP processing in vivo.

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Tyr(682) in the intracellular ...... ogenic APP processing in vivo.

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Alessia P M Barbagallo

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Luca Giliberto

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Oded Foreman

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Richard Weldon

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Robert Tamayev

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P2860

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

The amyloid-beta precursor protein: integrating structure with biological function

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

The amyloid precursor protein: beyond amyloid

Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?

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5

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Luciano D'Adamio

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2982846

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