about
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouseMuscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone productionNeutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and developmentExpression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension.Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice.Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation.Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland.Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted miceKey regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice.Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal.Decreased expression level of apoptosis-related genes and/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout miceDecreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.Genes regulated by caloric restriction have unique roles within transcriptional networks.Cardiac function in young and old Little mice.Growth Hormone's Effect on Adipose Tissue: Quality versus Quantity.Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality.Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice.A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer.Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics.Longevity Genes: From Primitive Organisms to Humans
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Is the Laron mouse an accurate model of Laron syndrome?
@ast
Is the Laron mouse an accurate model of Laron syndrome?
@en
type
label
Is the Laron mouse an accurate model of Laron syndrome?
@ast
Is the Laron mouse an accurate model of Laron syndrome?
@en
prefLabel
Is the Laron mouse an accurate model of Laron syndrome?
@ast
Is the Laron mouse an accurate model of Laron syndrome?
@en
P356
P1476
Is the Laron mouse an accurate model of Laron syndrome?
@en
P2093
P304
P356
10.1006/MGME.1999.2890
P577
1999-10-01T00:00:00Z