Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.
about
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2Human Ku70/80 interacts directly with hTR, the RNA component of human telomeraseThe human Rap1 protein complex and modulation of telomere lengthKu86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response elementMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.Telomeres, telomerase, and tumorigenesis--a reviewMouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaksDeletion of Ku70, Ku80, or both causes early aging without substantially increased cancerKu and the Stability of the GenomeDNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisKu interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.Human Ku70/80 associates physically with telomerase through interaction with hTERTA dual role for A-type lamins in DNA double-strand break repairDNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptaseThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlIncreased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsMammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sitesA p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrityNatural and pharmacological regulation of telomeraseATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.Effects of double-strand break repair proteins on vertebrate telomere structureKu86 is essential in human somatic cells.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometryDNA-PKcs is critical for telomere cappingThe absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cellsTelomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidenceRegulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joiningChromothripsis: breakage-fusion-bridge over and over again.
P2860
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P2860
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
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2000年論文
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2000年论文
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name
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@ast
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@en
type
label
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@ast
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@en
prefLabel
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@ast
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@en
P2093
P2860
P356
P1433
P1476
Mammalian Ku86 protein prevent ...... ats and the G-strand overhang.
@en
P2093
F A Goytisolo
M A Blasco
P P van Buul
P Slijepcevic
P2860
P304
P356
10.1093/EMBO-REPORTS/KVD051
P577
2000-09-01T00:00:00Z