The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
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Insight into the mode of action of the LRRK2 Y1699C pathogenic mutantThe G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsIs inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceEfficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activitiesPhysical and functional interaction between the ID1 and p65 for activation of NF-κBCellular effects of LRRK2 mutations.Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicityGlutathione metabolism and Parkinson's disease.LRRK2: cause, risk, and mechanism.The GTPase function of LRRK2.MASL1: a neglected ROCO protein.LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?Genetic, structural, and molecular insights into the function of ras of complex proteins domains.Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson diseaseMolecular Insights and Functional Implication of LRRK2 Dimerization.
P2860
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P2860
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@ast
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@en
type
label
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@ast
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@en
prefLabel
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@ast
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
@en
P2093
P2860
P1476
The R1441C mutation alters the folding properties of the ROC domain of LRRK2
@en
P2093
Brian Krumm
Elisa Greggio
Junpeng Deng
Laura Dunn
Mark R Cookson
Yongchao Li
P2860
P304
P356
10.1016/J.BBADIS.2009.09.010
P407
P577
2009-09-23T00:00:00Z