about
Internal IgH class switch region deletions are position-independent and enhanced by AID expressionToll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responsesAID targeting is dependent on RNA polymerase II pausing.The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationBroad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs)Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombinationUse of chromatin immunoprecipitation (ChIP) to detect transcription factor binding to highly homologous promoters in chromatin isolated from unstimulated and activated primary human B cells.Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B CellsS-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Class-switch recombination: after the dawn of AID.Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.Mismatch-mediated error prone repair at the immunoglobulin genes.Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination.Allergen-specific IgG1 provides parsimonious heritability estimates for atopy-associated immune responses to allergensNewly Identified TLR9 Stimulant, M6-395 Is a Potent Polyclonal Activator for Murine B CellsBinding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination.Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.Three-dimensional architecture of the IgH locus facilitates class switch recombination.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.Hesperidin-3'-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness.The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.Inducible DNA breaks in Ig S regions are dependent on AID and UNGThe 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes.Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factorGinsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells.Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Molecular processes that regulate class switching.
@ast
Molecular processes that regulate class switching.
@en
type
label
Molecular processes that regulate class switching.
@ast
Molecular processes that regulate class switching.
@en
prefLabel
Molecular processes that regulate class switching.
@ast
Molecular processes that regulate class switching.
@en
P1476
Molecular processes that regulate class switching.
@en
P2093
J Stavnezer
P304
P577
2000-01-01T00:00:00Z