The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae
about
tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerasesNatural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at High Temperatures in Arabidopsis thalianatRNA biology charges to the frontTemplate-dependent 3'-5' nucleotide addition is a shared feature of tRNAHis guanylyltransferase enzymes from multiple domains of lifeThe requirement for the highly conserved G-1 residue of Saccharomyces cerevisiae tRNAHis can be circumvented by overexpression of tRNAHis and its synthetase.Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.tRNAHis guanylyltransferase catalyzes a 3'-5' polymerization reaction that is distinct from G-1 additionChange of tRNA identity leads to a divergent orthogonal histidyl-tRNA synthetase/tRNAHis pairLife without post-transcriptional addition of G-1: two alternatives for tRNAHis identity in EukaryatRNAHis-guanylyltransferase establishes tRNAHis identityDoing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily.Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein.Identification of distinct biological functions for four 3'-5' RNA polymerases.
P2860
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P2860
The highly conserved tRNAHis guanylyltransferase Thg1p interacts with the origin recognition complex and is required for the G2/M phase transition in the yeast Saccharomyces cerevisiae
description
2005 nî lūn-bûn
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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2005 թվականի ապրիլին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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name
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@ast
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@en
type
label
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@ast
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@en
prefLabel
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@ast
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@en
P2093
P2860
P1433
P1476
The highly conserved tRNAHis g ...... yeast Saccharomyces cerevisiae
@en
P2093
David S Pederson
Nicholas H Heintz
Terri S Rice
P2860
P304
P356
10.1128/EC.4.4.832-835.2005
P577
2005-04-01T00:00:00Z