Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
about
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionRagulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6KGM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organizationRab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cellsInvolvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formationRal-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrinsImmunological function in mice lacking the Rac-related GTPase RhoGInvestigating the function of Rho family GTPases during Salmonella/host cell interactionsFaciogenital dysplasia protein (FGD1) regulates export of cargo proteins from the golgi complex via Cdc42 activation.Diacylglycerol kinase zeta regulates Ras activation by a novel mechanismIdentification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase RasP21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblastsInactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interferenceRapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruziRelease of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionSec16 influences transitional ER sites by regulating rather than organizing COPII.Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4.Nerve growth factor-dependent activation of the small GTPase RinStructural basis for the signaling specificity of RhoG and Rac1 GTPasesSmgGDS displays differential binding and exchange activity towards different Ras isoformsIIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphologyRegulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanismsRole of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cellsRab27a regulates the peripheral distribution of melanosomes in melanocytesViral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilizationp75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cellsRho GTPases and their effector proteinsIntegrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation.The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeastCdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cellsRac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor.RacG regulates morphology, phagocytosis, and chemotaxisR-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
P2860
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P2860
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@ast
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@en
type
label
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@ast
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@en
prefLabel
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@ast
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@en
P356
P1433
P1476
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.
@en
P2093
P2888
P356
10.1038/10018
P577
1999-06-01T00:00:00Z
P5875
P6179
1045007249