Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
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Modulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutationsStructural hot spots for the solubility of globular proteins.Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.Conformational stability as a design target to control protein aggregation.Coarse-grained model for colloidal protein interactions, B(22), and protein cluster formation.Therapeutic protein aggregation: mechanisms, design, and control.Role of anisotropic interactions for proteins and patchy nanoparticles.Comparative analysis of human γD-crystallin aggregation under physiological and low pH conditions.Structural integrity of the Greek key motif in βγ-crystallins is vital for central eye lens transparencyThe βγ-crystallins: native state stability and pathways to aggregation.Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils.Non-Arrhenius protein aggregation.Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation.Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lensesOrthogonal high-throughput thermal scanning method for rank ordering protein formulations.Protein stapling via azide-alkyne ligation.
P2860
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P2860
Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Computational design and bioph ...... rinsic aggregation propensity.
@ast
Computational design and bioph ...... rinsic aggregation propensity.
@en
type
label
Computational design and bioph ...... rinsic aggregation propensity.
@ast
Computational design and bioph ...... rinsic aggregation propensity.
@en
prefLabel
Computational design and bioph ...... rinsic aggregation propensity.
@ast
Computational design and bioph ...... rinsic aggregation propensity.
@en
P2093
P356
P1433
P1476
Computational design and bioph ...... trinsic aggregation propensity
@en
P2093
Andrea Naranjo
Christopher J Roberts
Erik J Fernandez
Erinc Sahin
Jacob L Jordan
Joseph A Costanzo
Michelle L Spatara
William F Weiss
P304
P356
10.1021/BI100978R
P407
P577
2011-01-13T00:00:00Z