Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
about
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn2+ fluorophores, kinetic, and X-ray crystallographic studyMetalloprotein–Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal–Ligand Interactions in a Metalloprotein Active SiteNucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitorsA Noncompetitive Inhibitor for Mycobacterium tuberculosis ’s Class IIa Fructose 1,6-Bisphosphate Aldolase‘Unconventional’ Coordination Chemistry by Metal Chelating Fragments in a Metalloprotein Active SiteDiscovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureusTargeting metalloproteins by fragment-based lead discovery.Exploring the influence of the protein environment on metal-binding pharmacophores.Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase.Computational exploration of zinc binding groups for HDAC inhibitionInhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.Fragment-Based Identification of Influenza Endonuclease Inhibitors.Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13.Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.Discovery of an Inhibitor of the Proteasome Subunit Rpn11.Clawing back: broadening the notion of metal chelators in medicineEmerging trends in metalloprotein inhibition.Investigating the selectivity of metalloenzyme inhibitors.Metal complexes and metalloproteases: targeting conformational diseases.3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.Synthesis and structure-activity relationship of 3-hydroxypyridine-2-thione-based histone deacetylase inhibitors.Morphological effects of MMPs inhibitors on the dentin bondingEvaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity.Grafting MAP peptide to dental polymer inhibits MMP-8 activity.3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors.A Bioinorganic Approach to Fragment-Based Drug Discovery Targeting Metalloenzymes.Effect of donor atom identity on metal-binding pharmacophore coordination.Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.Calorimetric studies of the interactions of metalloenzyme active site mimetics with zinc-binding inhibitors.5-Position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives.
P2860
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P2860
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@ast
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@en
type
label
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@ast
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@en
prefLabel
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@ast
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@en
P2860
P356
P1476
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
@en
P2093
Jessica L Fullagar
Melissa T Miller
P2860
P304
P356
10.1021/JM101266S
P407
P577
2010-12-28T00:00:00Z