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Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression

http://www.wikidata.org/entity/Q33783132

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Genetics and immunity in the era of single-cell genomics Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome The Many Alternative Faces of Macrophage Activation The virome in host health and disease Exploiting genomics and natural genetic variation to decode macrophage enhancers Searching for the human genetic factors standing in the way of universally effective vaccines How the Innate Immune System Senses Trouble and Causes Trouble Writ large: Genomic dissection of the effect of cellular environment on immune response Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease Phenotype and Tissue Expression as a Function of Genetic Risk in Polycystic Ovary Syndrome A regulatory polymorphism in HAVCR2 modulates susceptibility to HIV-1 infection The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin Genetics of gene expression in immunity to infection Network biology concepts in complex disease comorbidities Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes.Teaching 'big data' analysis to young immunologists.Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes.XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.Joint genetic analysis using variant sets reveals polygenic gene-context interactions.Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci The Antibody-Secreting Cell Response to Infection: Kinetics and Clinical Applications.Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression Non-Coding Loss-of-Function Variation in Human Genomes.Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.Enhancer variants: evaluating functions in common disease.

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Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression

http://www.wikidata.org/entity/Q33783132

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2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Innate immune activity conditi ...... upon monocyte gene expression

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Innate immune activity conditi ...... upon monocyte gene expression

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Innate immune activity conditi ...... upon monocyte gene expression

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Chris McGee

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Daniel Wong

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Evelyn Lau

http://www.w3.org/2001/XMLSchema#string

Katharine Plant

http://www.w3.org/2001/XMLSchema#string

Luke Jostins

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Robert Andrews

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Seiko Makino

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P2860

Model-based analysis of ChIP-Seq (MACS)

An integrated encyclopedia of DNA elements in the human genome

An integrated map of genetic variation from 1,092 human genomes

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Activities of IRF-1

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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scholarly article

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10.1126/SCIENCE.1246949

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6175

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343

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Julian C Knight

Benjamin P Fairfax

Vivek Naranbhai

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2014-03-01T00:00:00Z

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260611495

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24604202

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4064786

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