Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
about
Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDproFormation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis.Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicaseCellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex.Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDproRequirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis.Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of hepatitis C virus.Intracellular topology and epitope shielding of poliovirus 3A proteinRecombination of poliovirus RNA proceeds in mixed replication complexes originating from distinct replication start sites.Initiation of poliovirus negative-strand RNA synthesis requires precursor forms of p2 proteins.Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirusFoot-and-mouth disease.Poliovirus CRE-dependent VPg uridylylation is required for positive-strand RNA synthesis but not for negative-strand RNA synthesisTyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.Strand-specific RNA synthesis defects in a poliovirus with a mutation in protein 3A.Cis-active RNA elements (CREs) and picornavirus RNA replicationStrand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus.Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors.Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.Initiation of protein-primed picornavirus RNA synthesis.Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replicationPoliovirus requires a precise 5' end for efficient positive-strand RNA synthesis.Improving proteolytic cleavage at the 3A/3B site of the hepatitis A virus polyprotein impairs processing and particle formation, and the impairment can be complemented in trans by 3AB and 3ABC.Tomato ringspot virus proteins containing the nucleoside triphosphate binding domain are transmembrane proteins that associate with the endoplasmic reticulum and cofractionate with replication complexes.Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes.Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.The poly(A) binding protein is internalized in virus-induced vesicles or redistributed to the nucleolus during turnip mosaic virus infection.Evidence that insertion of Tomato ringspot nepovirus NTB-VPg protein in endoplasmic reticulum membranes is directed by two domains: a C-terminal transmembrane helix and an N-terminal amphipathic helix.Evidence for functional protein interactions required for poliovirus RNA replication.Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides.Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein.
P2860
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P2860
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@ast
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@en
type
label
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@ast
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@en
prefLabel
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@ast
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@en
P2093
P2860
P1433
P1476
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins
@en
P2093
B L Semler
J S Towner
M M Mazanet
P2860
P304
P577
1998-09-01T00:00:00Z