Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
about
Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactionsModulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutationsUnderstanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4Investigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry.Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.Aggregates of α-chymotrypsinogen anneal to access more stable statesTherapeutic protein aggregation: mechanisms, design, and control.Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1.Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scatteringAcid-induced aggregation propensity of nivolumab is dependent on the Fc.A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.Non-Arrhenius protein aggregation.A multiscale view of therapeutic protein aggregation: a colloid science perspective.Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering.Formation of multimeric antibodies for self-delivery of active monomers.Experimental Model System to Study pH Shift-Induced Aggregation of Monoclonal Antibodies Under Controlled Conditions.Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques.How do thermophilic proteins resist aggregation?Resolving power of dynamic light scattering for protein and polystyrene nanoparticles.Avoiding antibody aggregation during processing: establishing hold times.High-throughput screening and stability optimization of anti-streptavidin IgG1 and IgG2 formulations.Fibpredictor: a computational method for rapid prediction of amyloid fibril structures.Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress ConditionsModification of the kinetic stability of immunoglobulin G by solvent additives
P2860
Q27002558-04E515AF-4B05-4F21-8B86-71F5C3C82260Q30276839-CC1D3779-E010-4984-9DCF-F3CF28F7EA3FQ30357075-3F1F1926-B12D-4094-AE10-7A5722B2C12BQ30379478-3E0C365E-1B4D-4BAD-81E2-239B16803D45Q30422151-F551CB31-7123-4EE2-9E0C-89B4E072B8D3Q34090384-775A998C-CDAC-4024-BF02-27209E6D0455Q34097620-3BE5DB5B-7FEC-45C0-B73D-BDAFC0F2EF63Q35097145-DC1C1B8C-F879-4447-A6CB-A36272BACFA0Q35743857-9C6D33C5-A723-4DE2-B159-0E7701B16C04Q36100648-43111F83-3967-4406-8369-7A3DFD054EBBQ37141601-CA9C1ED7-9DCE-43E6-BE4D-01EDFA1753B2Q37287010-2596DC3F-DC40-4F05-8046-5E46C05B62F1Q38101467-2390969A-4EB4-4361-BDA6-6B45FC03ACFEQ38378651-F2CF62AF-DB4E-4AA4-B1AA-5EFE9306B775Q38611940-9F0F38B3-E07F-4310-AB9A-86E2066AF149Q38718139-B4B5ACBC-970F-4EA9-94E0-3491C250157BQ39958298-6C030A57-CB89-448A-8C59-FC4CDEBBB0D7Q40143552-DDE21878-F1C3-4D6A-B98B-AB29F3D6D7C7Q43014738-7CB2B892-4CC3-4BB8-AFC4-DECB439F554AQ43924528-D42737F9-B737-4F46-8CB9-FFE5D68D5D30Q44647316-A13E421D-DFFF-4B74-B3F8-928CA7E427DBQ46977209-A80C32A4-5F09-4C8C-88FC-201FB2EAFC7AQ51584586-A36A10A2-2537-4570-AEA5-9BAC0C30E504Q57665607-64C005F0-F0A0-4414-AA4B-211CB7AAF665Q57839816-8BA11B87-1F87-4355-939C-CCBA418698D0
P2860
Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@ast
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@en
type
label
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@ast
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@en
prefLabel
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@ast
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@en
P2093
P356
P1476
Nonnative aggregation of an Ig ...... h-molecular-weight aggregates.
@en
P2093
Christopher J Roberts
Douglas P Nesta
Liuquan Chang
Rebecca K Brummitt
Susan F Chase
Thomas M Laue
P304
P356
10.1002/JPS.22448
P407
P577
2011-01-06T00:00:00Z