Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell culture
about
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesisDiscrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirusImmune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γMutations in the M112/M113-coding region facilitate murine cytomegalovirus replication in human cells.A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge.Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infectionMurine cytomegalovirus immediate-early 1 gene expression correlates with increased GVHD after allogeneic hematopoietic cell transplantation in recipients reactivating from latent infection.CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivationMurine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse.A short cis-acting motif in the M112-113 promoter region is essential for IE3 to activate M112-113 gene expression and is important for murine cytomegalovirus replicationFunctional Dissection of an Alternatively Spliced Herpesvirus Gene by Splice Site MutagenesisCell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissuesProtective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cellsThe mouse cytomegalovirus immediate-early 1 gene is not required for establishment of latency or for reactivation in the lungs.Immune evasion proteins enhance cytomegalovirus latency in the lungs.Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection.Deletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency.The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.H2B homology region of major immediate-early protein 1 is essential for murine cytomegalovirus to disrupt nuclear domain 10, but is not important for viral replication in cell culture.Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription.Murine cytomegalovirus perturbs endosomal trafficking of major histocompatibility complex class I molecules in the early phase of infectionMurine cytomegalovirus major immediate-early protein 3 interacts with cellular and viral proteins in viral DNA replication compartments and is important for early gene activationTemporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes.The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells.
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P2860
Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell culture
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Elimination of ie1 significant ...... ative capacity in cell culture
@ast
Elimination of ie1 significant ...... ative capacity in cell culture
@en
type
label
Elimination of ie1 significant ...... ative capacity in cell culture
@ast
Elimination of ie1 significant ...... ative capacity in cell culture
@en
prefLabel
Elimination of ie1 significant ...... ative capacity in cell culture
@ast
Elimination of ie1 significant ...... ative capacity in cell culture
@en
P2093
P2860
P50
P1433
P1476
Elimination of ie1 significant ...... ative capacity in cell culture
@en
P2093
Astrid E Visser
Eva Maria Borst
Montse Gustems
Rosalía García
P2860
P304
P356
10.1128/JVI.79.11.7182-7194.2005
P577
2005-06-01T00:00:00Z