Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice - Wikidata - wikimedia - TriplyDB

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

http://www.wikidata.org/entity/Q33789872

about

Platelet generation in vivo and in vitro Hematopoietic stem cell expansion and generation: the ways to make a breakthrough Lost in translation: pluripotent stem cell-derived hematopoiesis Advances in cellular technology in the hematology field: What have we learned so far?Stem cells, megakaryocytes, and platelets Transcription factors in late megakaryopoiesis and related platelet disorders Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274 A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors Cationic surface charge combined with either vitronectin or laminin dictates the evolution of human embryonic stem cells/microcarrier aggregates and cell growth in agitated cultures.Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease.2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34⁺ haematopoietic stem cells.Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents.Manipulating megakaryocytes to manufacture platelets ex vivo.Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model.Platelet bioreactor: accelerated evolution of design and manufacture.Towards the Manufacture of Megakaryocytes and Platelets for Clinical Application.Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties The incredible journey: From megakaryocyte development to platelet formation.Platelet bioreactor-on-a-chip.Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.Road blocks in making platelets for transfusion G protein-dependent basal and evoked endothelial cell vWF secretion.Historical perspective and future directions in platelet research.De novo generation of HSCs from somatic and pluripotent stem cell sources.SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.Development of hematopoietic stem and progenitor cells from human pluripotent stem cells.Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.Microfluidic assessment of functional culture-derived platelets in human thrombi under flow.Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.Effect of Induced Pluripotent Stem Cell Technology in Blood Banking MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.Potential clinical applications for human pluripotent stem cell-derived blood components.Generation of mature hematopoietic cells from human pluripotent stem cells.

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Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

http://www.wikidata.org/entity/Q33789872

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2011年の論文

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Erin A Kimbrel

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Eunsil Hahm

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Feng Li

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Hong Yin

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Jaehyung Cho

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Jonathan N Thon

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Joseph E Italiano

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Qiang Feng

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Shi-Jiang Lu

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Wei Wang

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P2860

Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins

Induced pluripotent stem cell lines derived from human somatic cells

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.

Human induced pluripotent stem cells free of vector and transgene sequences

Mechanisms of organelle transport and capture along proplatelets during platelet production.

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

A critical role for extracellular protein disulfide isomerase during thrombus formation in mice.

Anti-GPIIb/IIIa drugs: current strategies and future directions.

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530-545

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10.1038/CR.2011.8

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3

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21

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21221130

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